慢性氯丙嗪药物撤药：一项实验分析。
Withdrawal of chronic chlorpromazine medication: an experimental analysis.
作者信息
Marholin D, Touchette P E, Stewart R M
出版信息
J Appl Behav Anal. 1979 Summer;12(2):159-71. doi: 10.1901/jaba.1979.12-159.
Abstract
Approximately 50% of all institutionalized, mentally retarded adults receive psychotropic medication to control inappropriate behavior. In this study, behaviors exhibited by five retarded adults were formally observed while they were on and off medication. Each subject had been receiving chlorpromazine for six or more years prior to the start of the study. The drug was withdrawn and readministered using a double-blind B-A-B (drug placebo-drug) design. Effects were highly individualized. Some desirable behavior emerged when chlorpromazine was discontinued.
摘要
约50%的所有被收容的成年智障者接受精神药物治疗以控制不当行为。在本研究中，对五名智障成年人在服药和停药期间的行为进行了正式观察。在研究开始前，每个受试者已接受氯丙嗪治疗六年或更长时间。采用双盲B - A - B（药物 - 安慰剂 - 药物）设计撤药并重新给药。效果高度个体化。停用氯丙嗪时出现了一些期望的行为。
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