Salas-Fraire Oscar, Rivera-Pérez Juan Antonio, Guevara-Neri Nancy P, Urrutia-García Krystle, Martínez-Gutiérrez Oscar A, Salas-Longoria Karina, Morales-Avalos Rodolfo
Department of Sports Medicine and Rehabilitation, University Hospital "Dr. José Eleuterio González", Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.
Department of Sports Medicine and Rehabilitation, University Hospital "Dr. José Eleuterio González", Universidad Autonoma de Nuevo Leon, Monterrey, Mexico; Department of Orthopedic Surgery and Traumatology, University Hospital "Dr. José Eleuterio González", Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.
J Orthop Sci. 2023 Jan;28(1):112-116. doi: 10.1016/j.jos.2021.10.006. Epub 2021 Nov 2.
Single arm, quasi-experimental study design.
To describe the effects of whole-body cryotherapy on pain, disability, and serum inflammatory markers in patients with chronic low back pain.
A quasi-experimental trial was performed on adult patients between 18 and 65 years with chronic low back pain. After obtaining informed consent, participants underwent 20 sessions of whole-body cryotherapy (at -160 °C) during a 5-week time span. Patient reported pain and disability measures (Pain Numerical Rating Scale [PNRS], Oswestry Disability Index [OSI], and Roland Morris Questionnaire [RMQ]) were obtained at each of the twenty sessions. Blood samples were obtained to analyze serum inflammatory markers at baseline, 10th and 20th session.
Forty-one participants were included in the study. A significant decrease was observed between the initial and final PNRS, ODI, and RMQ scores (p < 0.001). A significant reduction in the PNRS was found after 4 sessions of whole-body cryotherapy (p < 0.001). We observed decreasing values of pro-inflammatory serum marker IL-2 (p = 0.046) and a significant increase in the anti-inflammatory serum marker IL-10 (p = 0.003). No adverse events were reported during the study.
Whole-body cryotherapy is an effective therapy for pain and disability treatment in chronic low back pain. It also produces changes in serum markers of inflammation, decreasing pro-inflammatory markers and increasing anti-inflammatory markers.
单臂准实验研究设计。
描述全身冷冻疗法对慢性下腰痛患者疼痛、功能障碍和血清炎症标志物的影响。
对18至65岁的慢性下腰痛成年患者进行了一项准实验性试验。在获得知情同意后，参与者在5周的时间内接受了20次全身冷冻疗法（-160°C）。在20次治疗的每次治疗时，获取患者报告的疼痛和功能障碍测量指标（疼痛数字评定量表[PNRS]、Oswestry功能障碍指数[OSI]和罗兰·莫里斯问卷[RMQ]）。在基线、第10次和第20次治疗时采集血样以分析血清炎症标志物。
41名参与者纳入研究。观察到初始和最终的PNRS、ODI和RMQ评分之间有显著下降（p<0.001）。全身冷冻疗法4次后PNRS显著降低（p<0.001）。我们观察到促炎血清标志物IL-2值下降（p=0.046），抗炎血清标志物IL-10显著升高（p=0.003）。研究期间未报告不良事件。
全身冷冻疗法是治疗慢性下腰痛疼痛和功能障碍的有效疗法。它还会引起血清炎症标志物的变化，降低促炎标志物并增加抗炎标志物。
