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薰衣草、迷迭香和橙花精油对血液透析患者记忆问题和药物依从性的影响:一项平行随机对照试验。

The effects of lavender, rosemary and orange essential oils on memory problems and medication adherence among patients undergoing hemodialysis: A parallel randomized controlled trial.

机构信息

M.Sc. of critical care, Department of Critical Care Nursing, Razi Faculty of Nursing and Midwifery, Kerman University of Medical Sciences, Kerman, Iran.

Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

出版信息

Explore (NY). 2022 Sep-Oct;18(5):559-566. doi: 10.1016/j.explore.2021.10.004. Epub 2021 Oct 24.

DOI:10.1016/j.explore.2021.10.004
PMID:34736874
Abstract

BACKGROUND

hemodialysis patients' daily use of medications is essential for the disease management. One of the causes of medication non-adherence is that they forget to take medications, and non-adherence to treatment following memory loss is a common problem in patients on hemodialysis.

OBJECTIVE

the current study aimed to compare the effects of Lavender, Rosemary, and Orange essential oils on memory problems (both retrospective and prospective aspects of memory) and medication adherence in hemodialysis patients.

DESIGN

this study was a parallel randomized controlled trial.

SETTING

the two main hemodialysis centers in Kerman, southeastern Iran.

PARTICIPANTS

eighty-six patients under chronic hemodialysis were randomly allocated into four groups (Lavender, Rosemary, Orange, and control) by simple randomization method.

INTERVENTIONS

The samples of the intervention group, in addition to routine care, received Lavender or Rosemary or Orange essential oils three times a week for a month. A gauze containing with five drops of the essential oil was placed at a distance of 10 cm from the patient's nose one hour after hemodialysis, and the patient was asked to inhale it for 30 min.

MAIN OUTCOME MEASURES

retrospective and prospective memory, and medication adherence were assessed before, immediately and one month after the intervention.

RESULTS

prospective memory problems in Lavender, Rosemary and Orange groups did not change significantly over time (P > 0.05). Prospective memory problems in the control group had a significant increase (P = 0.002). No significant difference was found in prospective memory problems between the four groups (P > 0.05). Retrospective memory problems in the Lavender and Rosemary groups decreased significantly over time (P <0.05). The decreasing retrospective memory problems in the Orange and control groups were not statistically significant over time (P > 0.05). There was no significant difference in retrospective memory problems between the four groups (P > 0.05). No significant difference was observed between the four groups in medication adherence score during the study (P > 0.05).

CONCLUSION

aromatherapy with Lavender or Rosemary can reduce some memory problems in hemodialysis patients. However, the results of this study could not justify the effect of aromatherapy on the rate of medication adherence in patients on hemodialysis, so further studies are required.

TRIAL REGISTRATION

IRCT20190428043410N1.

摘要

背景

血液透析患者日常使用药物对疾病管理至关重要。药物依从性差的原因之一是他们忘记服药,而记忆力丧失后的治疗依从性是血液透析患者的常见问题。

目的

本研究旨在比较薰衣草、迷迭香和橙花精油对血液透析患者记忆问题(记忆的回顾性和前瞻性方面)和药物依从性的影响。

设计

这是一项平行随机对照试验。

地点

伊朗东南部克尔曼的两个主要血液透析中心。

参与者

86 名慢性血液透析患者通过简单随机分组法分为四组(薰衣草、迷迭香、橙花和对照组)。

干预措施

除常规护理外,干预组每周三次接受薰衣草或迷迭香或橙花精油治疗一个月。在血液透析后 1 小时,将含有 5 滴精油的纱布放在距患者鼻子 10 厘米的距离处,让患者吸入 30 分钟。

主要观察指标

在干预前、干预即刻和干预后 1 个月评估回顾性和前瞻性记忆以及药物依从性。

结果

薰衣草、迷迭香和橙花组的前瞻性记忆问题在时间上无显著变化(P>0.05)。对照组的前瞻性记忆问题显著增加(P=0.002)。四组之间的前瞻性记忆问题无显著差异(P>0.05)。薰衣草和迷迭香组的回顾性记忆问题随时间显著降低(P<0.05)。橙花和对照组的回顾性记忆问题随时间的变化不具有统计学意义(P>0.05)。四组之间的回顾性记忆问题无显著差异(P>0.05)。在研究期间,四组之间的药物依从性评分无显著差异(P>0.05)。

结论

薰衣草或迷迭香芳香疗法可以减轻血液透析患者的一些记忆问题。然而,本研究的结果不能证明芳香疗法对血液透析患者药物依从率的影响,因此需要进一步研究。

试验注册

IRCT20190428043410N1。

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