Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India.
Sri Sai College of Pharmacy, Manawala, Amritsar 143001, India.
Molecules. 2021 Jun 8;26(12):3489. doi: 10.3390/molecules26123489.
Roxb. (Boraginaceae) has been extensively used as a traditional remedy for the treatment of a diverse range of ailments related to the respiratory system, the gastrointestinal tract, the reproductive system, and against several infections. This review critically assesses and documents, for the first time, the fragmented information on , including its botanical description, folklore uses, bioactive phyto metabolites and pharmacological activities. The goal is to explore this plant therapeutically. Ethnomedicinal surveys reveal that has been used by tribal communities in Asian countries for the treatment of various disorders. Quantitative and qualitative phytochemical investigations of showed the presence of important phytoconstituents such as pentacyclic triterpenoids, phenolic acids, flavonoids, fatty acids, steroids, alkaloids, aliphatic alcohols, hydrocarbons, amino acids, carbohydrates, vitamins and minerals. Fresh plant parts, crude extracts, fractions and isolated compounds have been reported to exhibit broad spectrum of therapeutic activities viz., antioxidant, antiarthritic, antidiabetic, anti-inflammatory, antiulcer, antidiarrheal, antidysenteric, wound healing and anti-infective activities. is shown to be an excellent potential source of drugs for the mitigation of jaundice, asthma, dysentery, ulcers, diarrhea, ringworm, eczema, diabetes, fissure, syphilis, cuts and wounds, inflammation, liver problems, venereal and infectious disorders. Although few investigations authenticated its traditional uses but employed uncharacterized crude extracts of the plant, the major concerns raised are reproducibility of therapeutic efficacy and safety of plant material. The outcomes of limited pharmacological screening and reported bioactive compounds of suggest that there is an urgent need for in-depth pharmacological investigations of the plant.
罗克斯堡（紫草科）已被广泛用作传统药物，用于治疗与呼吸系统、胃肠道、生殖系统相关的多种疾病，并可用于多种感染的治疗。本次综述首次批判性地评估和记录了关于罗克斯堡的零散信息，包括其植物学描述、民间用途、生物活性植物代谢物和药理学活性。目的是探索这种植物的治疗潜力。民族医学调查显示，亚洲国家的部落社区一直将罗克斯堡用于治疗各种疾病。对罗克斯堡的定量和定性植物化学研究表明，存在重要的植物成分，如五环三萜、酚酸、类黄酮、脂肪酸、甾体、生物碱、脂肪醇、碳氢化合物、氨基酸、碳水化合物、维生素和矿物质。据报道，新鲜植物部分、粗提取物、馏分和分离化合物具有广泛的治疗活性，如抗氧化、抗关节炎、抗糖尿病、抗炎、抗溃疡、抗腹泻、抗痢疾、伤口愈合和抗感染活性。罗克斯堡被证明是一种极好的潜在药物来源，可以缓解黄疸、哮喘、痢疾、溃疡、腹泻、癣、湿疹、糖尿病、肛裂、梅毒、切割和伤口、炎症、肝脏问题、性病和传染病。尽管有一些调查证实了其传统用途，但使用的是该植物未经鉴定的粗提取物，主要关注的是治疗效果的重现性和植物材料的安全性。有限的药理学筛选结果和报道的罗克斯堡生物活性化合物表明，迫切需要对该植物进行深入的药理学研究。
