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锌指蛋白 460（ZNF460）诱导的线粒体翻译优化 1 同源物（CircMTO1）促进口腔鳞状细胞癌进展的机制是通过 microRNA miR-320a/α-地中海贫血/智力低下，X 连锁（ATRX）轴。

Circular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis.

机构信息

Foshan Stomatological Hospital, School of Medicine, Foshan University, Foshan, Guangdong, China.

Department of Oral and Maxillofacial Surgery, NanFang Hospital, Southern Medical University, Guangzhou, China.

出版信息

Bioengineered. 2021 Dec;12(2):9585-9597. doi: 10.1080/21655979.2021.1997699.

DOI:10.1080/21655979.2021.1997699
PMID:34738503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8810001/
Abstract

Oral squamous cell carcinoma (OSCC) is one of the most common cancer types of head and neck cancer, accounting for 95% of all cases. However, the mechanisms underlying the pathogenesis of OSCC remain unclear. Circular RNA (CircRNA) has been extensively studied in the past decades and is a promising direction for the development of OSCC therapeutic targets. In this study, we aimed to investigate the role of circMTO1 in OSCC progression. First, we validated the characterization and expression of circMTO1 in OSCC. It was found that circMTO1 was upregulated in OSCC tumor tissues and cells. Subsequently, we conducted biological experiments. It was found that circMTO1 knockdown inhibited OSCC cell proliferation, migration, and invasion. Furthermore, we conducted a series of experiments to elucidate the underlying mechanisms. A novel circMTO1/miR-320a/ATRX axis was identified. Our results suggest that circMTO1 modulates ATRX expression to accelerate OSCC progression by sponging miR-320a. Moreover, we found that circMTO1 expression in OSCC was transcriptionally regulated by Zinc Finger Protein 460 (ZNF460). Our study showed a novel ZNF460/circMTO1/miR-320a/ATRX signaling in OSCC development.

摘要

口腔鳞状细胞癌 (OSCC) 是头颈部癌症中最常见的癌症类型之一，占所有病例的 95%。然而，OSCC 发病机制的机制尚不清楚。环状 RNA (CircRNA) 在过去几十年中得到了广泛的研究，是开发 OSCC 治疗靶点的有前途的方向。在这项研究中，我们旨在研究 circMTO1 在 OSCC 进展中的作用。首先，我们验证了 circMTO1 在 OSCC 中的特征和表达。结果发现 circMTO1 在 OSCC 肿瘤组织和细胞中上调。随后，我们进行了生物学实验。结果发现 circMTO1 敲低抑制了 OSCC 细胞的增殖、迁移和侵袭。此外，我们进行了一系列实验来阐明潜在的机制。确定了一个新的 circMTO1/miR-320a/ATRX 轴。我们的结果表明，circMTO1 通过海绵 miR-320a 调节 ATRX 表达来加速 OSCC 进展。此外，我们发现 ZNF460 转录调控 OSCC 中的 circMTO1 表达。我们的研究表明，在 OSCC 发育过程中存在一个新的 ZNF460/circMTO1/miR-320a/ATRX 信号通路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/8810001/2c7e8aa8d700/KBIE_A_1997699_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/8810001/8f3bf551e52a/KBIE_A_1997699_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/8810001/6ff51a35f09f/KBIE_A_1997699_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/8810001/d695f99ceebc/KBIE_A_1997699_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/8810001/a4be2d9304c0/KBIE_A_1997699_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/8810001/88646d94d130/KBIE_A_1997699_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/8810001/f020b65500be/KBIE_A_1997699_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/8810001/2c7e8aa8d700/KBIE_A_1997699_F0007_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/8810001/8f3bf551e52a/KBIE_A_1997699_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/8810001/6ff51a35f09f/KBIE_A_1997699_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/8810001/d695f99ceebc/KBIE_A_1997699_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/8810001/a4be2d9304c0/KBIE_A_1997699_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/8810001/88646d94d130/KBIE_A_1997699_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/8810001/f020b65500be/KBIE_A_1997699_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/8810001/2c7e8aa8d700/KBIE_A_1997699_F0007_OC.jpg

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