a:1:{s:5:"en_US";s:45:"Ospedale Guglielmo da Saliceto, AUSL Piacenza";}.
Ospedale Guglielmo da Saliceto, AUSL, Piacenza.
Acta Biomed. 2021 Nov 3;92(5):e2021292. doi: 10.23750/abm.v92i5.9925.
The aim of this study was to evaluate the vaginal microbiota of women admitted to the hospital for premature labour and to compare the flora of those who responded to the tocolytic treatment with the flora of those who did not respond to the treatment and delivered prematurely Materials: the hospital records of 245 women admitted to the division of Obstetrics and Gynaecology of 'Guglielmo da Saliceto' Hospital in Piacenza for premature labour, between 24 completed weeks and 36 weeks plus 6 days of pregnancy, were reviewed and the results of vaginal swabs collected on admission were evaluated.
a vaginal dysbiosis, with reduction or absence of lactobacilli and presence of pathogenic microbial species, was found in all women admitted to the hospital for premature labour. Among them, 200 women (81,63%) responded to the tocolytic treatment while 45 women (18,36%) did not respond and delivered before 37 completed weeks. The four microbial species most prevalent in the vaginal flora were :Ureaplasma urealyticum, Streptococcus agalactiae, Candida albicans and Gardnerella vaginalis. When the characteristics of the vaginal flora of the two groups were compared, a more severe dysbiosis, with absence of lactobacilli and evidence of more than one pathogenic species, was found in 18% of women who responded to the tocolysis and in 71,4% of women who did not respond. The difference was statistically significant (p< 0,05, two-tailed test).
vaginal dysbiosis was diagnosed in all women admitted to the hospital for premature labour . A more severe dysbiosis, with complete absence of lactobacilli and presence of two or more pathogenic microbial species, was in the majority of women who showed no response to the tocolytic treatment compared to women with minor degrees of alteration of the vaginal flora.
本研究旨在评估因早产住院的女性的阴道微生物群，并比较对保胎治疗有反应与无反应且早产的女性的菌群。材料：对 245 名在皮亚琴扎的 Guglielmo da Saliceto 医院妇产科因早产住院的女性的医院记录进行了回顾，这些女性的妊娠周期在 24 周完整到 36 周加 6 天之间，评估了入院时采集的阴道拭子的结果。结果：所有因早产住院的女性均存在阴道菌群失调，表现为乳杆菌减少或缺失，以及致病性微生物物种的存在。其中，200 名女性（81.63%）对保胎治疗有反应，而 45 名女性（18.36%）无反应且在 37 周完整之前分娩。阴道菌群中最常见的四种微生物物种为 Ureaplasma urealyticum、Streptococcus agalactiae、Candida albicans 和 Gardnerella vaginalis。当比较两组阴道菌群的特征时，在对保胎治疗有反应的 18%女性和无反应的 71.4%女性中，发现更严重的菌群失调，乳杆菌缺失，且有超过一种的致病性物种存在。差异具有统计学意义（p<0.05，双侧检验）。结论：所有因早产住院的女性均诊断为阴道菌群失调。在对保胎治疗无反应的女性中，更严重的菌群失调，即乳杆菌完全缺失和两种或更多种致病性微生物物种存在，在大多数女性中更为常见，而在阴道菌群改变程度较轻的女性中则较少见。
