Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
School of Psychology and Counselling, Queensland University of Technology, Brisbane, Queensland, Australia.
Indoor Air. 2022 Jan;32(1):e12953. doi: 10.1111/ina.12953. Epub 2021 Nov 5.
Indoor air pollution is a recognized risk factor for a range of negative health outcomes. This study aimed to investigate the association between maternal prenatal exposure to indoor air pollution and the presence of autistic-like behaviors among preschool children. Data were obtained from the Longhua Child Cohort Study in 2017, in which we enrolled a total of 65 317 preschool children. Associations between maternal exposure to four sources of indoor air pollution (e.g., cooking, environmental tobacco smoke (ETS), mosquito coils, and home decoration) during pregnancy and preschool children's autistic traits were analyzed using multivariate logistic regression. Our results showed that maternal exposure to indoor air pollution from four different sources during pregnancy was associated with the presence of children's autistic-like behaviors. There was dose-response relationship between the accumulative exposure to the four different indoor air pollution sources and the risk of autistic-like behaviors. Furthermore, we found a significant additive interaction between prenatal exposure to both cooking and mosquito coil incense on the risk of autistic-like behaviors. Maternal prenatal exposure to the indoor air pollution from four sources might increase with the risk of autistic-like behaviors being present among preschool children, with an additive interaction effect between some pollution sources.
室内空气污染是一系列负面健康结果的公认风险因素。本研究旨在调查孕妇产前暴露于室内空气污染与学龄前儿童自闭症样行为之间的关系。数据来自 2017 年的龙华儿童队列研究，共纳入 65317 名学龄前儿童。使用多变量逻辑回归分析了孕妇怀孕期间接触四种室内空气污染源（如烹饪、环境烟草烟雾（ETS）、蚊香和家庭装修）与学龄前儿童自闭症特征之间的关联。我们的研究结果表明，孕妇怀孕期间接触四种不同来源的室内空气污染与儿童自闭症样行为的存在有关。四种不同室内空气污染源的累积暴露与自闭症样行为的风险之间存在剂量反应关系。此外，我们发现烹饪和蚊香暴露在产前对自闭症样行为风险的相互作用具有显著的加性。母亲产前接触四种来源的室内空气污染可能会增加学龄前儿童自闭症样行为的风险，一些污染源之间存在相加交互作用。
