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加拿大终生评估胎儿酒精谱系障碍个体的自杀倾向及相关因素。

Suicidality and Associated Factors Among Individuals Assessed for Fetal Alcohol Spectrum Disorder Across the Lifespan in Canada.

机构信息

Canada Fetal Alcohol Spectrum Disorder Research Network, Vancouver, British Columbia.

Werklund School of Education, 2129University of Calgary, Calgary, Alberta.

出版信息

Can J Psychiatry. 2022 May;67(5):361-370. doi: 10.1177/07067437211053288. Epub 2021 Nov 5.

Abstract

OBJECTIVE

Individuals with fetal alcohol spectrum disorder (FASD) experience a range of complex neurodevelopmental, psychological, and socioenvironmental vulnerabilities. There is growing evidence that suicidal ideation, attempts, and death by suicide are significant concerns within this population. In this study, we (1) determined the rate of suicidal ideation/attempts in a large group of individuals with prenatal alcohol exposure (PAE) who were assessed for FASD in Canada and (2) investigated the associations between suicidal ideation/attempts and select demographic and biopsychosocial factors in this group.

METHOD

A secondary analysis of data from Canada's National FASD Database, a national repository of clinical information gathered through FASD assessment and diagnostic clinics across the country, was conducted. Descriptive analyses, chi-square/Fisher's exact tests, and binary logistic regression were used to examine demographic and biopsychosocial variables and their associations with suicidality.

RESULTS

In our sample of 796 participants ( = 17.7 years, range = 6-59; 57.6% male) assessed for FASD, 25.9% were reported to experience suicidal ideation/attempts. Numerous demographic and biopsychosocial factors were found to be significantly associated with suicidal ideation/attempts. The strongest associations with suicidal ideation/attempts were substance use, history of trauma/abuse, and impaired affect regulation.

CONCLUSIONS

With this study, we contribute to the emerging evidence of elevated risk of suicidality among individuals with PAE/FASD and improve our understanding of factors that may exacerbate this risk. Findings have relevance for improving screening, prevention, and proactive treatment approaches for individuals with PAE and FASD, their families, and wider support systems.

摘要

目的

患有胎儿酒精谱系障碍(FASD)的个体经历一系列复杂的神经发育、心理和社会环境脆弱性。越来越多的证据表明,自杀意念、自杀企图和自杀死亡是该人群中的重要关注点。在这项研究中,我们(1)确定了在加拿大接受 FASD 评估的一大群有产前酒精暴露(PAE)的个体中自杀意念/企图的发生率,(2)研究了在该人群中自杀意念/企图与某些人口统计学和生物心理社会因素之间的关联。

方法

对加拿大国家 FASD 数据库的数据进行了二次分析,该数据库是一个全国性的临床信息存储库,通过全国范围内的 FASD 评估和诊断诊所收集。使用描述性分析、卡方/Fisher 精确检验和二项逻辑回归来检查人口统计学和生物心理社会变量及其与自杀倾向的关联。

结果

在我们的样本中,796 名参与者( = 17.7 岁,范围 6-59;57.6%为男性)接受了 FASD 评估,其中 25.9%报告有自杀意念/企图。许多人口统计学和生物心理社会因素与自杀意念/企图显著相关。与自杀意念/企图最强相关的因素是物质使用、创伤/虐待史和情绪调节受损。

结论

通过这项研究,我们为有 PAE/FASD 的个体自杀风险升高的这一新兴证据做出了贡献,并提高了我们对可能加剧这种风险的因素的理解。这些发现与改善对有 PAE 和 FASD 的个体及其家庭和更广泛的支持系统的筛查、预防和主动治疗方法有关。

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