Iudina I E, Fedorova K N
Biull Eksp Biol Med. 1987 May;103(5):573-5.
It has been shown using labelled modified AO cytofluorometry of DNP cellular thermal denaturation that the melting profiles of peripheral blood cellular chromatin in children with acute lympholeukemia (ALL) were of strictly individual, "unclassifiable" nature and were similar to those of their mothers but different from those of their fathers and healthy people, which seems in favour of a possible connection between the disease under study and the peculiarities of the mother's genotype. Similar types of deviations have been found in the structure of interphase chromatin of healthy parents of children with ALL. Such a combination of changes in the parents' genotype may prove unfavourable, increasing the birth rate of neonates with a genetic predisposition to the disease in question.
使用标记的改良AO细胞荧光光度法对DNP细胞热变性进行研究，结果表明，急性淋巴细胞白血病（ALL）患儿外周血细胞染色质的解链曲线具有严格的个体性、“不可分类”的性质，与患儿母亲的相似，但与患儿父亲及健康人的不同，这似乎支持了所研究疾病与母亲基因型特征之间可能存在的联系。在ALL患儿健康父母的间期染色质结构中也发现了类似类型的偏差。父母基因型的这种变化组合可能是不利的，会增加具有该疾病遗传易感性的新生儿出生率。
