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Prospective, simultaneous assessment of joint and vascular inflammation by PET/CT in tofacitinib-treated patients with rheumatoid arthritis: associations with vascular and bone status.

作者信息

Hamar Attila, Hascsi Zsolt, Pusztai Anita, Czókolyová Monika, Végh Edit, Pethő Zsófia, Gulyás Katalin, Soós Boglárka, Kerekes György, Szekanecz Éva, Hodosi Katalin, Szántó Sándor, Szűcs Gabriella, Seres Tamás, Szekanecz Zoltán, Szamosi Szilvia

机构信息

Division of Rheumatology, University of Debrecen, Faculty of Medicine, Debrecen, Hungary.

Scanomed Ltd, Debrecen, Hungary.

出版信息

RMD Open. 2021 Nov;7(3). doi: 10.1136/rmdopen-2021-001804.

DOI:10.1136/rmdopen-2021-001804
PMID:34740980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8573670/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33d9/8573670/9f367a443a04/rmdopen-2021-001804f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33d9/8573670/e827ef9a9b74/rmdopen-2021-001804f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33d9/8573670/ed780845b57f/rmdopen-2021-001804f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33d9/8573670/9f367a443a04/rmdopen-2021-001804f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33d9/8573670/e827ef9a9b74/rmdopen-2021-001804f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33d9/8573670/ed780845b57f/rmdopen-2021-001804f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33d9/8573670/9f367a443a04/rmdopen-2021-001804f03.jpg

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Prospective, simultaneous assessment of joint and vascular inflammation by PET/CT in tofacitinib-treated patients with rheumatoid arthritis: associations with vascular and bone status.托法替布治疗的类风湿关节炎患者中通过PET/CT对关节和血管炎症进行前瞻性同步评估：与血管和骨骼状态的关联
RMD Open. 2021 Nov;7(3). doi: 10.1136/rmdopen-2021-001804.
2
Comparing the effects of tofacitinib, methotrexate and the combination, on bone marrow oedema, synovitis and bone erosion in methotrexate-naive, early active rheumatoid arthritis: results of an exploratory randomised MRI study incorporating semiquantitative and quantitative techniques.比较托法替布、甲氨蝶呤及其联合用药对初治早期活动性类风湿关节炎患者骨髓水肿、滑膜炎和骨侵蚀的影响：一项纳入半定量和定量技术的探索性随机MRI研究结果
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本文引用的文献

1
Effects of tofacitinib therapy on arginine and methionine metabolites in association with vascular pathophysiology in rheumatoid arthritis: A metabolomic approach.托法替布治疗对类风湿关节炎中与血管病理生理学相关的精氨酸和蛋氨酸代谢产物的影响：一种代谢组学方法。
Front Med (Lausanne). 2022 Nov 10;9:1011734. doi: 10.3389/fmed.2022.1011734. eCollection 2022.
2
Effects of one-year tofacitinib therapy on bone metabolism in rheumatoid arthritis.托法替布治疗类风湿关节炎对骨代谢的影响。
Osteoporos Int. 2021 Aug;32(8):1621-1629. doi: 10.1007/s00198-021-05871-0. Epub 2021 Feb 9.
3
Arterial wall inflammation is increased in rheumatoid arthritis compared with osteoarthritis, as a marker of early atherosclerosis.
Understanding Cardiovascular Events With JAK Inhibitors: Tofacitinib Reduces Synovial and Vascular Inflammation but not the Prothrombotic Effects of Inflammatory Cytokines on Endothelium.
了解JAK抑制剂与心血管事件的关系：托法替布可减轻滑膜和血管炎症，但不能减轻炎性细胞因子对内皮的促血栓形成作用。
ACR Open Rheumatol. 2025 Jan;7(1):e11790. doi: 10.1002/acr2.11790.
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Role of PET/CT in diagnosing and monitoring disease activity in rheumatoid arthritis: a review.PET/CT 在类风湿关节炎的诊断和疾病活动监测中的作用：综述。
Ann Nucl Med. 2024 Mar;38(3):165-175. doi: 10.1007/s12149-023-01896-z. Epub 2024 Jan 26.
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Efficacy and safety of JAK inhibitors in rheumatoid arthritis: update for the practising clinician.JAK 抑制剂在类风湿关节炎中的疗效和安全性：临床医生的最新进展。
Nat Rev Rheumatol. 2024 Feb;20(2):101-115. doi: 10.1038/s41584-023-01062-9. Epub 2024 Jan 12.
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Effect of tofacitinib therapy on angiotensin converting enzyme activity in rheumatoid arthritis.托法替布治疗对类风湿关节炎中血管紧张素转换酶活性的影响。
Front Med (Lausanne). 2023 Oct 9;10:1226760. doi: 10.3389/fmed.2023.1226760. eCollection 2023.
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Rheumatology (Oxford). 2023 Oct 23;62(SI3):SI304-SI312. doi: 10.1093/rheumatology/kead502.
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Drug Saf. 2023 Nov;46(11):1049-1071. doi: 10.1007/s40264-023-01333-0. Epub 2023 Jul 25.
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Front Med (Lausanne). 2022 Nov 10;9:1011734. doi: 10.3389/fmed.2022.1011734. eCollection 2022.
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Effects of One-Year Tofacitinib Therapy on Lipids and Adipokines in Association with Vascular Pathophysiology in Rheumatoid Arthritis.托法替布治疗 1 年对类风湿关节炎血管病理生理学相关的血脂和脂肪因子的影响。
Biomolecules. 2022 Oct 14;12(10):1483. doi: 10.3390/biom12101483.
动脉壁炎症在类风湿关节炎中比骨关节炎中更为增加，作为早期动脉粥样硬化的标志物。
Rheumatology (Oxford). 2021 Jul 1;60(7):3360-3368. doi: 10.1093/rheumatology/keaa789.
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Osteoporosis in patients with rheumatoid arthritis: an update in epidemiology, pathogenesis, and fracture prevention.类风湿关节炎患者的骨质疏松症：流行病学、发病机制和骨折预防的更新。
Expert Opin Pharmacother. 2020 Oct;21(14):1725-1737. doi: 10.1080/14656566.2020.1787381. Epub 2020 Jul 1.
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Common mechanisms and holistic care in atherosclerosis and osteoporosis.动脉粥样硬化和骨质疏松症的共同机制与整体护理。
Arthritis Res Ther. 2019 Jan 10;21(1):15. doi: 10.1186/s13075-018-1805-7.
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Semin Arthritis Rheum. 2019 Feb;48(4):720-727. doi: 10.1016/j.semarthrit.2018.05.007. Epub 2018 May 18.
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F- FDG PET/CT joint assessment of early therapeutic response in rheumatoid arthritis patients treated with rituximab.利妥昔单抗治疗的类风湿关节炎患者早期治疗反应的 F-FDG PET/CT 联合评估
Eur J Hybrid Imaging. 2018;2(1):6. doi: 10.1186/s41824-017-0022-y. Epub 2018 Feb 5.
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Tofacitinib improves atherosclerosis despite up-regulating serum cholesterol in patients with active rheumatoid arthritis: a cohort study.托法替布可改善动脉粥样硬化，尽管可上调活动期类风湿关节炎患者的血清胆固醇：一项队列研究。
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