Department of Laboratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifu Yuan, Dongcheng District, Beijing, 100730, China.
State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100730, China.
BMC Cardiovasc Disord. 2021 Nov 6;21(1):526. doi: 10.1186/s12872-021-02328-4.
Serum lipid concentrations are affected by long-term high-fat diets; thus, we hypothesize that lipid levels increase after the Spring Festival in China.
In total, 20,192 individuals (male: n=10,108, female: n=10,084) were enrolled in this retrospective cross-sectional study based on clinical data from the Laboratory Information System (LIS) and Hospital Information System (HIS) in Peking Union Medical College Hospital from 2014 to 2018. Total cholesterol (TC), triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were analyzed.
The serum TC [male vs. female: (4.71 ± 0.90 vs. 4.56 ± 0.85) mmol/L], TG [male vs. female: (1.71 ± 1.56 vs. 1.02 ± 0.68) mmol/L], and LDL-C [male vs. female: (3.01 ± 0.77 vs. 2.73 ± 0.74) mmol/L] levels were significantly higher in males than in females (P < 0.001); serum HDL-C [male vs. female: (1.18 ± 0.28 vs. 1.50 ± 0.34) mmol/L] was significantly lower in males (P < 0.001). In February, the TC, TG, and LDL-C levels were 8.4%, 16.3%, and 9.3% higher than the lowest levels recorded, respectively. The prevalence of dyslipidemia of the two weeks before the Spring festival was significantly lower than that of the first week after the Spring festival (43.6% (168/385) vs. 54.1% (126/233), P=0.007). Additionally, the prevalence of dyslipidemia was statistically higher in the first week after the Spring Festival than in May-January.
Higher TC, TG, and LDL-C in winter could be associated with high-fat diets during the Spring Festival. The Spring Festival was immediately followed by a higher lipid concentrations. Thus, we don't recommend lipid assessment or physical examination immediately after the holiday especially Spring festival.
血清脂质浓度受长期高脂肪饮食的影响；因此，我们假设在中国春节后脂质水平会升高。
本回顾性横断面研究基于北京协和医院实验室信息系统（LIS）和医院信息系统（HIS）从 2014 年至 2018 年的临床数据，共纳入 20192 名个体（男性：n=10108，女性：n=10084）。分析总胆固醇（TC）、甘油三酯（TGs）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）。
男性血清 TC[男性与女性：（4.71±0.90 与 4.56±0.85）mmol/L]、TG[男性与女性：（1.71±1.56 与 1.02±0.68）mmol/L]和 LDL-C[男性与女性：（3.01±0.77 与 2.73±0.74）mmol/L]水平明显高于女性（P<0.001）；男性血清 HDL-C[男性与女性：（1.18±0.28 与 1.50±0.34）mmol/L]明显低于女性（P<0.001）。2 月 TC、TG 和 LDL-C 水平分别比最低水平高出 8.4%、16.3%和 9.3%。春节前两周的血脂异常患病率明显低于春节后第一周（43.6%（168/385）比 54.1%（126/233），P=0.007）。此外，春节后第一周血脂异常的患病率明显高于 5-1 月。
冬季 TC、TG 和 LDL-C 升高可能与春节期间的高脂肪饮食有关。春节后紧接着是脂质浓度升高。因此，我们不建议在假期后特别是春节后立即进行血脂评估或体检。
