College of Pharmacy and Institute of Drug Research and Development, Chungnam National University, Daejeon, South Korea.
Arch Pharm Res. 2021 Dec;44(12):1051-1061. doi: 10.1007/s12272-021-01360-4. Epub 2021 Nov 7.
Vascular smooth muscle cell (VSMC) proliferation and migration are critical events that contribute to the pathogenesis of vascular diseases such as atherosclerosis, restenosis, and hypertension. Recent findings have revealed that VSMC phenotype switching is associated with metabolic switch, which is related to the role of mitochondria. Mitochondrial dynamics are directly associated with mitochondrial function and cellular homeostasis. Interestingly, it has been suggested that mitochondrial dynamics and mitophagy play crucial roles in the regulation of VSMC proliferation and migration through various mechanisms. Especially, dynamin-related protein-1 and mitofusion-2 are two main molecules that play a key role in regulating mitochondrial dynamics to induce VSMC proliferation and migration. Therefore, this review describes the function and role of mitochondrial dynamics and mitophagy in VSMC homeostasis as well as the underlying mechanisms. This will provide insight into the development of innovative approaches to treat atherosclerosis.
血管平滑肌细胞（VSMC）增殖和迁移是导致血管疾病（如动脉粥样硬化、再狭窄和高血压）发病机制的关键事件。最近的研究结果表明，VSMC 表型转换与代谢转换有关，而代谢转换与线粒体的作用有关。线粒体动力学与线粒体功能和细胞内稳态直接相关。有趣的是，已经有人提出，线粒体动力学和线粒体自噬通过多种机制在调节 VSMC 增殖和迁移方面发挥着至关重要的作用。特别是，动力相关蛋白 1 和线粒体融合蛋白 2 是调节线粒体动力学以诱导 VSMC 增殖和迁移的两个主要分子。因此，本综述描述了线粒体动力学和线粒体自噬在 VSMC 动态平衡中的功能和作用，以及潜在的机制。这将为开发治疗动脉粥样硬化的创新方法提供思路。
