Division of Pulmonary and Critical Care, School of Medicine, University of Miami, 1951 NW 7th Ave, Suite 2308, Miami, FL, 33136, USA.
Division of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
BMC Public Health. 2021 Nov 7;21(1):2036. doi: 10.1186/s12889-021-12123-7.
Non-communicable diseases (NCDs) are an increasing global concern, with morbidity and mortality largely occurring in low- and middle-income settings. We established the prospective Rural Uganda Non-Communicable Disease (RUNCD) cohort to longitudinally characterize the NCD prevalence, progression, and complications in rural Africa.
We conducted a population-based census for NCD research. We systematically enrolled adults in each household among three sub-counties of the larger Nakaseke Health district and collected baseline demographic, health status, and self-reported chronic disease information. We present our data on self-reported chronic disease, as stratified by age, sex, educational attainment, and sub-county.
A total of 16,694 adults were surveyed with 10,563 (63%) respondents enrolled in the self-reported study. Average age was 37.8 years (SD = 16.5) and 45% (7481) were male. Among self-reported diseases, hypertension (HTN) was most prevalent (6.3%). 1.1% of participants reported a diagnosis of diabetes, 1.1% asthma, 0.7% COPD, and 0.4% kidney disease. 2.4% of the population described more than one NCD. Self-reported HTN was significantly higher in the peri-urban subcounty than in the other two rural sub-counties (p < 0.001); diagnoses for all other diseases did not differ significantly between sub-counties. Odds for self-reported HTN increased significantly with age (OR = 1.87 per 10 years of age, 95% CI 1.78-1.96). Male sex was associated with lower odds of reporting asthma (OR = 0.53, 95% CI 0.34-0.82) or HTN (OR = 0.31, 95% CI 0.26-0.40).
The RUNCD will establish one of the largest NCD patient cohorts in rural Africa. First analysis highlights the feasibility of systematically enrolling large numbers of adults living in a rural Ugandan district. In addition, our study demonstrates low levels of self-reported NCDs compared to the nation-wide established levels, emphasizing the need to better educate, characterize, and care for the majority of rural communities.
非传染性疾病（NCDs）是一个日益严重的全球问题，发病率和死亡率主要发生在中低收入国家和地区。我们建立了前瞻性乌干达农村非传染性疾病（RUNCD）队列，以对农村非洲的 NCD 患病率、进展和并发症进行纵向描述。
我们进行了一项基于人群的 NCD 研究普查。我们在更大的纳卡塞克卫生区的三个分区中对每个家庭的成年人进行了系统的登记，并收集了基线人口统计学、健康状况和自我报告的慢性疾病信息。我们根据年龄、性别、教育程度和分区呈现了自我报告的慢性疾病数据。
共有 16694 名成年人接受了调查，其中 10563 名（63%）受访者参加了自我报告的研究。平均年龄为 37.8 岁（标准差=16.5），45%（7481 人）为男性。在自我报告的疾病中，高血压（HTN）最为常见（6.3%）。有 1.1%的参与者报告了糖尿病的诊断，1.1%的参与者报告了哮喘，0.7%的参与者报告了 COPD，0.4%的参与者报告了肾脏疾病。有 2.4%的人群描述了超过一种 NCD。城市周边分区的自我报告高血压患病率明显高于其他两个农村分区（p<0.001）；其他疾病的诊断在分区之间没有显著差异。自我报告高血压的可能性随着年龄的增加而显著增加（每增加 10 岁，OR=1.87，95%CI 1.78-1.96）。男性的性别与报告哮喘（OR=0.53，95%CI 0.34-0.82）或高血压（OR=0.31，95%CI 0.26-0.40）的可能性降低相关。
RUNCD 将建立非洲农村最大的 NCD 患者队列之一。首次分析强调了系统招募乌干达农村地区大量成年人的可行性。此外，我们的研究表明，与全国范围内已建立的水平相比，自我报告的 NCD 水平较低，这强调了需要更好地教育、描述和照顾大多数农村社区的必要性。
