College of Health Sciences, Makerere University, Kampala, Uganda.
MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda.
PLoS One. 2019 Aug 9;14(8):e0221022. doi: 10.1371/journal.pone.0221022. eCollection 2019.
Antiretroviral therapy (ART) has changed the course of HIV/AIDs by enabling patients to live longer, raising concern of the co- existence of HIV with other chronic illnesses, notably non-communicable diseases (NCDs). NCDs are on the rise in developing countries and evidence shows higher occurrence among people living with HIV (PLHIV). In Uganda, the burden of NCDs among PLHIV remains largely unquantified.
To determine the prevalence of hypertension, osteoporosis, diabetes mellitus, renal impairment, asthma, cardiomyopathy and multi-morbidity among HIV positive patients, receiving Anti-Retroviral Therapy at Joint Clinical Research Centre, Lubowa, Uganda.
This was a cross-sectional study conducted among 387 systematically sampled patients, receiving ART at the Joint Clinical Research Centre, Lubowa, between March and April 2017. The study used data extracted from routine care patient files to identify individuals with non-communicable diseases. Prevalence of the NCDs was estimated and reported with 95% confidence intervals. Prevalence was also reported at various levels of socio- demographic, behavioural and clinical factors.
The overall prevalence of having at least one NCD was 20.7% (95% CI: 16.7-24.5). The prevalence of hypertension was 12.4% (95% CI: 9.1-15.7), osteoporosis 6.5% (95% CI: 4.0-8.9), diabetes mellitus 4.7% (95% CI: 2.6-6.8), renal impairment 1.6% (95% CI: 0.3-2.8), asthma 1.6% (95% CI: 0.3-2.8), and cardiomyopathy 1.3% (95% CI: 0.2-2.4). Prevalence of multi-morbidity was 4.7% (95% CI: 2.6-6.8). Prevalence was significantly higher among older participants, widowed participants and individuals with an opportunistic infection.
Non-communicable diseases are common among people living with HIV. There is need to encourage early diagnosis and treatment of non-communicable diseases in PLHIV in Uganda.
抗逆转录病毒疗法（ART）通过使患者寿命延长，改变了 HIV/AIDS 的进程，由此引发了人们对 HIV 与其他慢性疾病（主要是非传染性疾病，NCDs）共同存在的担忧。NCDs 在发展中国家呈上升趋势，有证据表明，NCDs 在 HIV 感染者（PLHIV）中的发病率更高。在乌干达，PLHIV 中 NCDs 的负担在很大程度上仍未得到量化。
确定在乌干达卢瓦瓦联合临床研究中心接受抗逆转录病毒治疗的 HIV 阳性患者中高血压、骨质疏松症、糖尿病、肾功能损害、哮喘、心肌病和多种疾病的患病率。
这是一项横断面研究，于 2017 年 3 月至 4 月在卢瓦瓦联合临床研究中心对 387 名系统抽样的患者进行。该研究使用从常规护理患者档案中提取的数据来确定患有非传染性疾病的个体。估计并报告了 NCD 的患病率，并报告了 95%置信区间内的患病率。还报告了在各种社会人口、行为和临床因素水平下的患病率。
至少有一种 NCD 的总患病率为 20.7%（95%CI：16.7-24.5）。高血压患病率为 12.4%（95%CI：9.1-15.7），骨质疏松症为 6.5%（95%CI：4.0-8.9），糖尿病为 4.7%（95%CI：2.6-6.8），肾功能损害为 1.6%（95%CI：0.3-2.8），哮喘为 1.6%（95%CI：0.3-2.8），心肌病为 1.3%（95%CI：0.2-2.4）。多种疾病的患病率为 4.7%（95%CI：2.6-6.8）。年龄较大的参与者、丧偶的参与者和患有机会性感染的参与者中，患病率显著更高。
非传染性疾病在 HIV 感染者中很常见。乌干达需要鼓励对 PLHIV 进行早期诊断和治疗非传染性疾病。
