Department of Surgery, Federal University of Ceará, Fortaleza, Brazil.
Postgraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.
Breast Dis. 2022;41(1):123-132. doi: 10.3233/BD-201032.
Although widely studied, the role of HPV in the genesis of breast carcinomas remains elusive due to the diversity of results across studies, possibly caused by the wide methodological heterogeneity, some of them with inadequate methods.
To verify the association between HPV and breast cancer through the meta-analysis of studies that used the best-recognized techniques for viral detection and tissue conservation.
A systematic review and meta-analysis restricted to studies that detected HPV by PCR in fresh and frozen tissue from breast cancer were conducted to obtain greater homogeneity. PubMed, Scopus, Science Direct, Cochrane Library, and SciELO were searched until December 14, 2019. Search terms included "breast cancer" and "HPV" without language restrictions. Eleven studies were included in the meta-analysis. The pooled relative risks and 95% confidence interval (95% CI) were calculated, and heterogeneity was assessed using the I-squared (I2).
The selected studies had very low heterogeneity (2%). There is a 2.15 times higher combined relative risk (95% CI = 1.60-2.89) of detecting HPV in breast cancer than in cancer-free breast controls with a statistically significant p-value (p < 0.0001).
Our data support the association of DNA-HPV with breast carcinomas. Further studies are needed to find out which breast cancer subtypes this association is most frequent.
尽管 HPV 在乳腺癌的发生中的作用已经得到广泛研究，但由于研究结果的多样性，其作用仍然难以确定，这可能是由于方法学的广泛异质性造成的，其中一些方法不够完善。
通过对使用最公认的病毒检测和组织保存技术的研究进行荟萃分析，验证 HPV 与乳腺癌之间的关联。
系统检索并荟萃分析了在乳腺癌新鲜和冷冻组织中使用 PCR 检测 HPV 的研究，以获得更大的同质性。检索 PubMed、Scopus、Science Direct、Cochrane Library 和 SciELO，检索时间截至 2019 年 12 月 14 日。检索词包括“乳腺癌”和“HPV”，不限制语言。共有 11 项研究纳入荟萃分析。计算了合并的相对风险和 95%置信区间（95%CI），并使用 I 平方（I2）评估了异质性。
所选研究的异质性非常低（2%）。与癌旁正常乳腺组织相比，乳腺癌中 HPV 的联合相对风险（95%CI=1.60-2.89）高出 2.15 倍，具有统计学显著意义（p<0.0001）。
我们的数据支持 HPV 与乳腺癌之间的关联。需要进一步研究以确定这种关联在哪些乳腺癌亚型中更为常见。
