Saeedi-Moghaddam Fateme, Mohammaditabar Mahdi, Mozhgani Sayed-Hamidreza
Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran.
Department of Microbiology and Virology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.
Retrovirology. 2024 Dec 3;21(1):20. doi: 10.1186/s12977-024-00653-y.
The role of viruses in the development of breast cancer has been a subject of debate and extensive research over the past few decades. Several studies have examined the association between Bovine leukemia virus (BLV) infection and the risk of developing breast cancer; however, their findings have yielded inconsistent results. To address this uncertainty, the purpose of the present study was to conduct a systematic review and meta-analysis to determine any potential association between BLV and breast cancer.
The literature search was performed by finding related articles from PubMed, Web of Science, Scopus, EMBASE, and ScienceDirect databases. Statistical analysis was conducted using the meta package in R Studio and Review Manager 5.1. The I test was used to assess between-study heterogeneity. The Mantel-Haenszel method calculated the pooled odds ratio and its 95% confidence interval. Studies were divided into subgroups for comparison.
The literature search identified a total of 17 studies that were deemed suitable for inclusion in the systematic review. Out of these 17 studies, 12 were used in the subsequent meta-analysis. Combining the data from these eligible studies, we calculated the pooled multi-factor adjusted odds ratio (OR) and a 95% confidence interval (CI). Considering the heterogeneity observed across the studies, the result obtained using the fixed effects model was 2.12 (1.77, 2.54). However, upon removing the six studies that contributed significantly to the heterogeneity, the pooled OR with a 95% CI was recalculated to be 3.92 (2.98, 5.16).
The result of this study suggests that BLV infection is statistically associated with Breast cancer.
在过去几十年中，病毒在乳腺癌发展中的作用一直是一个争论和广泛研究的主题。几项研究探讨了牛白血病病毒（BLV）感染与患乳腺癌风险之间的关联；然而，他们的研究结果并不一致。为了解决这一不确定性，本研究的目的是进行系统评价和荟萃分析，以确定BLV与乳腺癌之间是否存在任何潜在关联。
通过在PubMed、科学网、Scopus、EMBASE和ScienceDirect数据库中查找相关文章进行文献检索。使用R Studio中的meta包和Review Manager 5.1进行统计分析。I检验用于评估研究间的异质性。Mantel-Haenszel方法计算合并比值比及其95%置信区间。将研究分为亚组进行比较。
文献检索共确定了17项被认为适合纳入系统评价的研究。在这17项研究中，有12项用于随后的荟萃分析。综合这些合格研究的数据，我们计算了合并的多因素调整比值比（OR）和95%置信区间（CI）。考虑到各研究间观察到的异质性，使用固定效应模型得到的结果为2.12（1.77，2.54）。然而，在剔除对异质性有显著贡献的6项研究后，重新计算的合并OR及其95%CI为3.92（2.98，5.16）。
本研究结果表明，BLV感染与乳腺癌在统计学上相关。
