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退伍军人事务医疗中心双侧乳内动脉移植项目的发展历程

Evolution of Bilateral Mammary Arterial Grafting Program in Veterans Affairs Medical Center.

作者信息

Wang Sue X, Lee Michelle, Chang Chih-Chiun, Lai Lillian Y Y, Flores Nick, Ge Liang, Wozniak Curtis J, Tseng Elaine E

机构信息

University of California San Francisco and San Francisco VA Medical Center, Department of Surgery, San Francisco, CA.

出版信息

J Heart Valve Dis. 2019;28(2):59-66.

Abstract

BACKGROUND

Coronary revascularization with bilateral internal mammary arteries is associated with increased long-term survival, but underutilized due to sternal wound infection concerns. Dedicated bilateral mammary grafting programs are typically high-volume academic or private practices, rather than lower-volume federal institutions whose results are not captured in the Society of Thoracic Surgeons database. Our institution used only single internal mammary arterial grafting in the year prior to implementing a dedicated bilateral grafting program using skeletonized technique. We describe our experience transitioning to bilateral mammary grafting and its impact on sternal wound infection.

METHODS

Retrospective cohort study at San Francisco Veterans Affairs Medical Center in 200 patients undergoing first-time isolated, multi-vessel coronary artery bypass from August 2014 to October 2017. Sternal wound infection was defined broadly to include any patient receiving antibiotics for suspicion of sternal infection. Patients were followed for wound complications until 3 post-operative months.

RESULTS

Of 200 total patients, 45.5% (n=91) were diabetic, 44% (n=88) had BMI >30, and 61.5% (n=123) underwent bilateral mammary grafting. Bilateral mammary grafting population had 2.4% (n=3/123) deep sternal wound infection with 1.6% (n=2/123) requiring sternal reconstruction while single mammary population had 1.3% (n=1/77, p=1.0). Bilateral mammary grafting population had 6.5% (n=8/123) superficial sternal wound infection compared to 5.2% (n=4/77, p=0.77) in single mammary grafting population.

CONCLUSIONS

Transitioning to high rates of bilateral mammary utilization was possible in a year with low rates of complications. Based on our experience, surgeons should consider adopting a skeletonized bilateral mammary grafting approach given potential long-term survival benefit.

摘要

背景

采用双侧乳内动脉进行冠状动脉血运重建与长期生存率提高相关,但由于担心胸骨伤口感染,其应用未得到充分利用。专门的双侧乳腺移植项目通常是高容量的学术或私人机构,而非低容量的联邦机构,其结果未被纳入胸外科医师协会数据库。在实施使用骨骼化技术的专门双侧移植项目之前的一年,我们机构仅使用单支乳内动脉移植。我们描述了向双侧乳腺移植过渡的经验及其对胸骨伤口感染的影响。

方法

对2014年8月至2017年10月在旧金山退伍军人事务医疗中心接受首次孤立多支冠状动脉搭桥手术的200例患者进行回顾性队列研究。胸骨伤口感染的定义广泛,包括任何因怀疑胸骨感染而接受抗生素治疗的患者。对患者的伤口并发症进行随访,直至术后3个月。

结果

在200例患者中,45.5%(n = 91)患有糖尿病,44%(n = 88)的体重指数>30,61.5%(n = 123)接受了双侧乳腺移植。双侧乳腺移植人群中有2.4%(n = 3/123)发生深部胸骨伤口感染,其中1.6%(n = 2/123)需要进行胸骨重建,而单支乳腺移植人群中有1.3%(n = 1/77,p = 1.0)。双侧乳腺移植人群中有6.5%(n = 8/123)发生浅表胸骨伤口感染,而单支乳腺移植人群中有5.2%(n = 4/77,p = 0.77)。

结论

在并发症发生率较低的一年中,有可能实现双侧乳腺高利用率的转变。根据我们的经验,鉴于潜在的长期生存益处,外科医生应考虑采用骨骼化双侧乳腺移植方法。

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