Chang Sherilyn, Jeyagurunathan Anitha, Lau Jue Hua, Shafie Saleha, Samari Ellaisha, Cetty Laxman, Mok Yee Ming, Verma Swapna, Subramaniam Mythily
Research Division, Institute of Mental Health, Singapore, Singapore.
Department of Mood and Anxiety, Institute of Mental Health, Singapore, Singapore.
Front Psychiatry. 2021 Oct 22;12:762988. doi: 10.3389/fpsyt.2021.762988. eCollection 2021.
Problematic drug use is common among psychiatric patients and is linked with poorer course and outcomes of illness. The aim of this study is to assess the prevalence of problematic drug use, and to explore its sociodemographic correlates and associations with health behaviors and outcomes among outpatients with schizophrenia and related psychoses in Singapore. Data from 397 individuals who were aged 21-65 years and were seeking treatment for schizophrenia and related psychoses in the outpatient clinics of a tertiary psychiatric hospital were analyzed. The Drug Abuse Screening Test (DAST-10) was used to assess problematic drug use. Information on sociodemographics, smoking status, alcohol use, symptoms severity and quality of life were collected. Multivariable logistic regressions were conducted to explore correlates and associations of problematic drug use. The prevalence of problematic drug use was 5.8% ( = 23) in the sample, and 10.6% ( = 42) of the participants reported having problematic drug use and/or problematic alcohol use. More males than females reported having problematic drug use ( = 0.021), and also problematic drug and/or alcohol use ( = 0.004). Significant associations were observed between problematic drug use and smokers with nicotine dependence, and with physical health domain of quality of life. Individuals with greater symptom severity were approximately twice as likely to have problematic drug use and/or alcohol use. While the prevalence of problematic drug use in this sample population is relatively lower compared to other countries, there is a considerable number who might be at risk. Routine screening and close monitoring of drug use is recommended as part of psychiatric assessment, particularly among males and patients with nicotine dependence.
问题性药物使用在精神科患者中很常见，并且与疾病的较差病程和结局相关。本研究的目的是评估问题性药物使用的患病率，并探讨其社会人口学相关因素以及与新加坡精神分裂症及相关精神病门诊患者的健康行为和结局之间的关联。分析了来自一家三级精神病医院门诊诊所的397名年龄在21 - 65岁之间、正在寻求精神分裂症及相关精神病治疗的患者的数据。使用药物滥用筛查测试（DAST - 10）来评估问题性药物使用情况。收集了有关社会人口学、吸烟状况、饮酒情况、症状严重程度和生活质量的信息。进行多变量逻辑回归以探讨问题性药物使用的相关因素和关联。样本中问题性药物使用的患病率为5.8%（n = 23），10.6%（n = 42）的参与者报告有问题性药物使用和/或问题性酒精使用。报告有问题性药物使用的男性多于女性（p = 0.021），报告有问题性药物和/或酒精使用的男性也多于女性（p = 0.004）。在问题性药物使用与有尼古丁依赖的吸烟者以及生活质量的身体健康领域之间观察到显著关联。症状严重程度较高的个体有问题性药物使用和/或酒精使用的可能性大约是其他人的两倍。虽然该样本人群中问题性药物使用的患病率与其他国家相比相对较低，但仍有相当数量的人可能处于风险中。建议将药物使用的常规筛查和密切监测作为精神科评估的一部分，特别是在男性和有尼古丁依赖的患者中。
