GENEWIZ Inc., Suzhou, China.
Department of General Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China.
Front Endocrinol (Lausanne). 2021 Oct 22;12:747646. doi: 10.3389/fendo.2021.747646. eCollection 2021.
Obesity, especially central obesity, is a strong risk factor for developing type 2 diabetes (T2D). However, the mechanism underlying the progression from central obesity to T2D remains unknown. Therefore, we analyzed the gut microbial profiles of central obese individuals with or without T2D from a Chinese population. Here we reported both the microbial compositional and gene functional alterations during the progression from central obesity to T2D. Several opportunistic pathogens were enriched in obese T2D patients. We also characterized thousands of genes involved in sugar and amino acid metabolism whose abundance were significantly depleted in obese T2D group. Moreover, the abundance of those genes was negatively associated with plasma glycemia level and percentage of individuals with impaired plasma glucose status. Therefore, our study indicates that the abundance of those depleted genes can be used as a potential biomarker to identify central obese individuals with high risks of developing T2D.
肥胖，尤其是中心型肥胖，是 2 型糖尿病（T2D）发生的一个强烈危险因素。然而，从中心型肥胖进展到 T2D 的机制尚不清楚。因此，我们分析了来自中国人群的伴或不伴 T2D 的中心型肥胖个体的肠道微生物特征。在此，我们报道了从中型肥胖进展到 T2D 过程中微生物组成和功能的变化。在肥胖 T2D 患者中，几种机会性病原体被富集。我们还鉴定了数千个参与糖和氨基酸代谢的基因，其在肥胖 T2D 组中的丰度明显减少。此外，这些基因的丰度与血浆血糖水平和糖代谢受损个体的比例呈负相关。因此，我们的研究表明，这些减少的基因的丰度可用作识别具有发展为 T2D 高风险的中心型肥胖个体的潜在生物标志物。
