（Miq.）Miq. 对四氧嘧啶诱导的糖尿病大鼠的降血糖、降血脂及肝保护作用。

Antihyperglycemic, antihyperlipidemic and hepatoprotective effects of (Miq.) Miq. supplementation in alloxan-induced diabetic rats.

作者信息

Aloke Chinyere, Nwachukwu Ngwu, Obasi Nwogo Ajuka, Emelike Chinedum Uche, Amu Pascal Anyaegbunam, Ogbu Patience Nkemjika, Orinya Onyebuchi Federick, Ogbonnia Egwu Chinedu

机构信息

Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Alex Ekwueme Federal University, Ndufu-Alike, Abakaliki, Nigeria.

Department of Biochemistry, Faculty of Sciences, Federal University of Technology, Owerri, Imo State, Nigeria.

出版信息

Avicenna J Phytomed. 2021 Sep-Oct;11(5):428-435. doi: 10.22038/AJP.2020.16958.

DOI:10.22038/AJP.2020.16958

PMID:34745915

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8554283/

Abstract

OBJECTIVE

Medicinal plants provide better and cheaper alternative therapy for management of several diseases compared to orthodox medicines. This study evaluated the effects of feed formulated with (Miq.) Miq. (FFFO) leaves in the management of alloxan-induced diabetes mellitus (DM) in rats.

MATERIALS AND METHODS

DM was induced in overnight-fasted rats by administration of alloxan monohydrate intraperitoneally. DM rats in Groups 1-3 were fed with graded FFFO while group 4 (diabetic control) and group 5 (normal control) were fed with commercial feeds (Vital-Feeds), daily for 21 days. Changes in body weight and some biochemical parameters were thereafter determined.

RESULTS

Results showed significant decreases (p<0.05) in serum high-density lipoprotein (HDL) but significant increases (p<0.05) in blood glucose, serum low-density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC) and alanine aminotransferase (ALT) activities in DM-induced rats compared to the normal control group. Feeding with FFFO significantly increased (p<0.05) the body weight and HDL, decreased the blood glucose, serum LDL, TG and TC and attenuated ALT activities in FFFO-fed DM rats compared to the diabetic control group.

CONCLUSION

This study revealed that FFFO-diet may mitigate hyperglycemia, dyslipidemia and liver-damage associated with DM.

摘要

目的

与传统药物相比，药用植物为多种疾病的治疗提供了更好且更便宜的替代疗法。本研究评估了用（Miq.）Miq.（FFFO）叶配制的饲料对大鼠四氧嘧啶诱导的糖尿病（DM）的治疗效果。

材料与方法

对禁食过夜的大鼠腹腔注射一水合四氧嘧啶诱导糖尿病。第1 - 3组的糖尿病大鼠喂食不同梯度的FFFO，而第4组（糖尿病对照组）和第5组（正常对照组）喂食商业饲料（Vital - Feeds），每天一次，持续21天。之后测定体重和一些生化参数的变化。

结果

结果显示，与正常对照组相比，糖尿病诱导大鼠的血清高密度脂蛋白（HDL）显著降低（p<0.05），但血糖、血清低密度脂蛋白（LDL）、甘油三酯（TG）、总胆固醇（TC）和丙氨酸氨基转移酶（ALT）活性显著升高（p<0.05）。与糖尿病对照组相比，喂食FFFO显著增加了（p<0.05）FFFO喂养的糖尿病大鼠的体重和HDL，降低了血糖、血清LDL、TG和TC，并减弱了ALT活性。