Ferreira Rosilene Gomes da Silva, Guilhon-Simplicio Fernanda, Acho Leonard Domingo Rosales, Batista Nayana Yared, Guedes-Junior Frank do Carmo, Ferreira Mayla Silva Leão, Barcellos José Fernando Marques, Veiga-Junior Valdir Florêncio, Lima Emerson Silva
Superior Normal School, Amazonas State University, Djalma Batista 2470, Chapada, 69050-010, Manaus, Manaus, AM, Brazil.
Faculty of Pharmaceutical Sciences, Federal University of Amazonas, General Rodrigo Otávio 6200, Coroado 1, 69080-900, Manaus, AM, Brazil.
Avicenna J Phytomed. 2021 Sep-Oct;11(5):451-463. doi: 10.22038/AJP.2021.18076.
Diabetes, obesity, and their associated metabolic disorders are public health problems that require prevention and new efficient drugs for treatment. We evaluated the anti-hyperglycemic, lipid-lowering, and anti-obesity effects of semisynthetic α, β-amyrenones (ABA).
BALB/c mice were used for performing an acute model of oral carbohydrate and triglyceride tolerance, and in a streptozotocin-induced diabetes model, where glycemia and body weight changes were measured during ten days. C57BL/6 strain mice were used in the diet-induced obesity model, where lipidemia and body weight were measured during four weeks, and biochemical and histological parameters were analyzed after euthanasia. The doses considered in this study were 25, 50, and 100 mg/kg of ABA, used following some criteria for each experiment.
ABA 25 mg/kg reduced the postprandial glycemia peak higher than acarbose 50 mg/kg (p<0.05). ABA 50 mg/kg significantly reduced glycemia in diabetic mice compared to acarbose 50 mg/kg (p<0.05). There was a reduction in the weight of the obese animals treated with ABA 25 and 50 mg/kg (p<0.05). ABA 50 mg/kg also significantly reduced lipidemia in these animals compared to orlistat 50 mg/kg.
This study presents evidence of ABA's action in reducing postprandial glycemia and obesity in mice.
糖尿病、肥胖及其相关的代谢紊乱是需要预防和新型高效治疗药物的公共卫生问题。我们评估了半合成α,β-香树脂酮（ABA）的降糖、降脂和抗肥胖作用。
使用BALB/c小鼠建立口服碳水化合物和甘油三酯耐量急性模型，以及链脲佐菌素诱导的糖尿病模型，在10天内测量血糖和体重变化。使用C57BL/6品系小鼠建立饮食诱导的肥胖模型，在4周内测量血脂和体重，并在安乐死后分析生化和组织学参数。本研究中考虑的剂量为25、50和100mg/kg的ABA，每个实验根据一些标准使用。
25mg/kg的ABA降低餐后血糖峰值的效果高于50mg/kg的阿卡波糖（p<0.05）。与50mg/kg的阿卡波糖相比，50mg/kg的ABA显著降低了糖尿病小鼠的血糖（p<0.05）。用25和50mg/kg的ABA治疗的肥胖动物体重减轻（p<0.05）。与50mg/kg的奥利司他相比，50mg/kg的ABA也显著降低了这些动物的血脂。
本研究提供了ABA在降低小鼠餐后血糖和肥胖方面作用的证据。
