Carvalho Karine Maria Martins Bezerra, Marinho Filho José Delano Barreto, de Melo Tiago Sousa, Araújo Ana Jérsia, Quetz Josiane da Silva, da Cunha Maria do Perpétuo Socorro Saldanha, de Melo Karina Moura, da Silva Armenio Andre de Carvalho Almeida, Tomé Adriana Rocha, Havt Alexandre, Fonseca Said Gonçalves da Cruz, Brito Gerly Anne de Castro, Chaves Mariana Helena, Rao Vietla Satyanarayana, Santos Flávia Almeida
Post-Graduate Programme in Medical Sciences, Faculty of Medicine, Federal University of Ceará, 60430-140 Fortaleza, CE, Brazil ; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, 60430-270 Fortaleza, CE, Brazil.
Faculty of Pharmacy, Odontology and Nurse, Federal University of Ceará, 60430-160 Fortaleza, CE, Brazil.
Evid Based Complement Alternat Med. 2015;2015:106157. doi: 10.1155/2015/106157. Epub 2015 Jan 29.
Herbal compounds rich in triterpenes are well known to regulate glucose and lipid metabolism and to have beneficial effects on metabolic disorders. The present study investigated the antiobesity properties of resin from Protium heptaphyllum (RPH) and the possible mechanisms in mice fed a high-fat diet (HFD) for 15 weeks. Mice treated with RPH showed decreases in body weight, net energy intake, abdominal fat accumulation, plasma glucose, amylase, lipase, triglycerides, and total cholesterol relative to their respective controls, which were RPH unfed. Additionally, RPH treatment, while significantly elevating the plasma level of ghrelin hormone, decreased the levels of insulin, leptin, and resistin. Besides, HFD-induced increases in plasma levels of proinflammatory mediators TNF-α, IL-6, and MCP-1 were significantly lowered by RPH. Furthermore, in vitro studies revealed that RPH could significantly inhibit the lipid accumulation in 3T3-L1 adipocytes (measured by Oil-Red O staining) at concentrations up to 50 μg/mL. These findings suggest that the antiobese potential of RPH is largely due to its modulatory effects on various hormonal and enzymatic secretions related to fat and carbohydrate metabolism and to the regulation of obesity-associated inflammation.
富含三萜类化合物的草药成分以调节葡萄糖和脂质代谢以及对代谢紊乱具有有益作用而闻名。本研究调查了七叶普罗梯木树脂（RPH）对喂食高脂饮食（HFD）15周的小鼠的抗肥胖特性及其可能的机制。与未喂食RPH的各自对照组相比，接受RPH治疗的小鼠体重、净能量摄入、腹部脂肪堆积、血浆葡萄糖、淀粉酶、脂肪酶、甘油三酯和总胆固醇均有所下降。此外，RPH治疗虽然显著提高了胃饥饿素激素的血浆水平，但降低了胰岛素、瘦素和抵抗素的水平。此外，RPH显著降低了HFD诱导的促炎介质TNF-α、IL-6和MCP-1血浆水平的升高。此外，体外研究表明，RPH在浓度高达50μg/mL时可显著抑制3T3-L1脂肪细胞中的脂质积累（通过油红O染色测量）。这些发现表明，RPH的抗肥胖潜力很大程度上归因于其对与脂肪和碳水化合物代谢相关的各种激素和酶分泌的调节作用以及对肥胖相关炎症的调节。
