Department of Pediatrics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
Hailiang Hospital, Zhuji, Zhejiang Province, China.
Aging (Albany NY). 2021 Nov 8;13(21):24236-24250. doi: 10.18632/aging.203676.
Though central precocious puberty (CPP) as a disease that seriously affects the development of a child is increasing year by year, treatment options remain limited and is the same as the 1980s' method. These are mainly due to the complex pathogenesis of central precocious puberty. Therefore, systems biology approach to identify and explore the multiple factors related to the pathogenesis of central precocious puberty is necessary. Our data established the first proteome profile of CPP revealed 163 down-regulated and 129 were up-regulated differentially expressed proteins. These altered proteins were primarily enriched in three metabolic process including energy metabolism, amino acid metabolism and nitrogenous base metabolism. The identified altered members of the metabolic signaling are valuable and potential novel therapeutic targets of central precocious puberty.
虽然中枢性性早熟（CPP）作为一种严重影响儿童发育的疾病，其发病率正逐年上升，但治疗选择仍然有限，与 20 世纪 80 年代的方法相同。这主要是由于中枢性性早熟的发病机制复杂。因此，有必要采用系统生物学方法来识别和探讨与中枢性性早熟发病机制相关的多种因素。我们的数据建立了 CPP 的第一个蛋白质组图谱，揭示了 163 个下调和 129 个上调的差异表达蛋白。这些改变的蛋白质主要富集在三个代谢过程中，包括能量代谢、氨基酸代谢和含氮碱基代谢。所鉴定的代谢信号改变成员是有价值的和潜在的中枢性性早熟的新的治疗靶点。
