Department of Chemistry, DAV University, Jalandhar, Punjab, India.
Department of Chemistry, UGC Sponsored Centre for Advanced Studies-II, Guru Nanak Dev University, Amritsar, Punjab, India.
Prog Mol Biol Transl Sci. 2021;184:145-178. doi: 10.1016/bs.pmbts.2021.08.001. Epub 2021 Sep 14.
The aggregation-induced emission (AIE) active bioprobes are known for their high photostability and extraordinary signal to noise ratio. In view of this, research efforts to synthesize new AIE bioimaging probes are at an incredible speed. In this chapter, we have summarized the various lysosome specific AIE active "turn-on" bioprobes having applications in lysosome imaging, monitoring of lysosome bioactivity and evaluation of their therapeutic effects. By discussing their design and operational mechanisms, we hope to provide more insight into designing new AIE bioprobes for specific sensing and imaging of lysosome having flexibility for broad range of biomedical applications.
聚集诱导发光（AIE）活性生物探针以其高稳定性和非凡的信噪比而闻名。有鉴于此，人们正在以惊人的速度合成新的 AIE 生物成像探针。在本章中，我们总结了各种溶酶体特异的 AIE 活性“开启”生物探针，它们在溶酶体成像、溶酶体生物活性监测以及治疗效果评估方面具有应用。通过讨论它们的设计和工作机制，我们希望为设计用于特定溶酶体感应和成像的新型 AIE 生物探针提供更多的见解，这些探针具有广泛的生物医学应用的灵活性。
