Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.
Division of Ophthalmology, Itami City Hospital, Itami, Japan.
Sci Rep. 2021 Nov 9;11(1):21947. doi: 10.1038/s41598-021-01557-z.
Although choriocapillaris flow deficit (CFD) around choroidal neovascularization (CNV) is less associated with CNV activity in myopic eyes, no reports are investigating its size as an indicator of CNV activity. We investigated the relationship between CFD and high myopia-related CNV. In this retrospective, observational study, patients underwent optical coherence tomography angiography (OCTA) with split-spectrum amplitude-decorrelation angiography for diagnosing pathological myopic CNV (mCNV); CFD features around CNV margins were evaluated. Of the 33 eyes (30 patients), 11 (33.3%) had active mCNV, and 22 (66.7%) had inactive CNV. Six eyes (18.2%) were treatment-naïve, while the remainder previously underwent anti-vascular endothelial growth factor therapy. On OCTA, blood flow signals were detected in CNV in the outer retinal layer in 28 (84.8%) eyes, including all active cases (11 cases) and 17 (77.3%) of 22 inactive cases. CNV flow signal size correlated significantly with activity (P < 0.001). CFD around CNV was observed in 24 eyes (72.7%), including all active cases (11 cases) and 13 (59.1%) of 22 inactive cases. CFD size correlated significantly with CNV activity (P < 0.001). The size of both the CFD area around CNV and CNV flow signal area are useful indicators of CNV activity in eyes with mCNV, which may help determine treatment timing.
虽然脉络膜毛细血管血流不足（CFD）与近视眼中脉络膜新生血管（CNV）的活动相关性较低，但目前尚无报道探讨其大小作为 CNV 活动的指标。我们研究了 CFD 与高度近视相关 CNV 的关系。在这项回顾性、观察性研究中，患者接受了光学相干断层扫描血管造影（OCTA）检查，采用谱域光相干断层扫描血管造影（split-spectrum amplitude-decorrelation angiography）诊断病理性近视性脉络膜新生血管（mCNV）；评估了 CNV 边缘周围 CFD 的特征。在 33 只眼中（30 位患者），11 只眼（33.3%）存在活动性 mCNV，22 只眼（66.7%）存在非活动性 CNV。6 只眼（18.2%）为初治患者，其余患者之前接受过抗血管内皮生长因子治疗。在 OCTA 上，28 只眼（84.8%）在外视网膜层检测到 CNV 的血流信号，包括所有活动性病例（11 例）和 22 例非活动性病例中的 17 例（77.3%）。CNV 血流信号大小与活动度显著相关（P<0.001）。在 24 只眼（72.7%）中观察到 CNV 周围的 CFD，包括所有活动性病例（11 例）和 22 例非活动性病例中的 13 例（59.1%）。CFD 大小与 CNV 活动度显著相关（P<0.001）。CNV 周围 CFD 面积和 CNV 血流信号面积的大小均是 mCNV 患者 CNV 活动的有用指标，可能有助于确定治疗时机。
