Yang Yanni, Li Daning, Wu Wentao, Huang Dingxing, Zheng Haishi, Aihaiti Yirixiati
School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, People's Republic of China.
Shaanxi University of Traditional Chinese Medicine, Xianyang, Shaanxi, People's Republic of China.
Int J Gen Med. 2021 Oct 30;14:7471-7485. doi: 10.2147/IJGM.S332031. eCollection 2021.
Selenium (Se) exhibits its anti-carcinogenic properties by regulating the redox system. However, the relationship between selenoprotein P (SeP), mRNA ( mRNA) and tumorigenesis remains unclear. Plasma SeP transports Se to various target tissues and has antioxidant characteristics. The present study aimed to explore the multifaceted pan-cancer properties of in terms of its tissue-specific expression, prognostic value, immune function, and signaling pathway enrichment.
The expression profile of was determined in 33 tumor types and survival, pathway enrichment, and correlation analyses were conducted based on TCGA database. The relationship between expression and immune infiltration and macrophage subtype gene markers was investigated using the TIMER and GEPIA.
gene expression was decreased in many cancer tissues, but was upregulated in brain lower grade glioma (LGG). Furthermore, expression was associated with a better prognosis in most cancers, but a poorer prognosis in LGG and uterine corpus endometrioid carcinoma (UCEC). Our results showed that was correlated with infiltration level of six immune cell types, where also showed a strong correlation with macrophages in some cancer types. However, we failed to determine macrophage polarization in 33 tumor types. negatively regulated vascular endothelial cell proliferation in LGG and UCEC and epidermal cell differentiation in six tumor types. In contrast, upregulation was related to immune function, including T cell activation, B cell-mediated immunity, adaptive immune response and immune response regulation cell surface receptor signaling pathways in another six tumor types.
These findings highlighted the tissue-specific expression, prognostic value and immune characteristics of in pan-cancer, and provided insights for illustrating the role of in tumorigenesis.
硒（Se）通过调节氧化还原系统发挥其抗癌特性。然而，硒蛋白P（SeP）、信使核糖核酸（mRNA）与肿瘤发生之间的关系仍不明确。血浆SeP将硒转运至各种靶组织，并具有抗氧化特性。本研究旨在从其组织特异性表达、预后价值、免疫功能和信号通路富集等方面探索SeP的多方面泛癌特性。
基于TCGA数据库确定SeP在33种肿瘤类型中的表达谱，并进行生存、通路富集和相关性分析。使用TIMER和GEPIA研究SeP表达与免疫浸润及巨噬细胞亚型基因标志物之间的关系。
许多癌组织中SeP基因表达降低，但在脑低级别胶质瘤（LGG）中上调。此外，SeP表达在大多数癌症中与较好的预后相关，但在LGG和子宫内膜样癌（UCEC）中与较差的预后相关。我们的结果表明，SeP与六种免疫细胞类型的浸润水平相关，在某些癌症类型中SeP也与巨噬细胞有很强的相关性。然而，我们未能在33种肿瘤类型中确定巨噬细胞极化情况。SeP在LGG和UCEC中负向调节血管内皮细胞增殖，在六种肿瘤类型中负向调节表皮细胞分化。相反，在另外六种肿瘤类型中，SeP上调与免疫功能相关，包括T细胞活化、B细胞介导的免疫、适应性免疫反应和免疫反应调节细胞表面受体信号通路。
这些发现突出了SeP在泛癌中的组织特异性表达、预后价值和免疫特征，并为阐明SeP在肿瘤发生中的作用提供了见解。
