LIPH在乳腺癌中的预后价值及临床意义
Prognostic Value and Clinical Significance of LIPH in Breast Cancer.
作者信息
Gao Peng, Liu Qiang, Ai Bolun, Fang Yi, Wang Zhongzhao, Wang Jing
机构信息
Department of Breast Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, People's Republic of China.
出版信息
Int J Gen Med. 2021 Nov 2;14:7613-7623. doi: 10.2147/IJGM.S332233. eCollection 2021.
BACKGROUND
Lipase member H (LIPH), a novel member of the mammalian triglyceride lipase family, is localized on human chromosome 3q27-q28. Exploration of the importance of the new cancer-related gene LIPH in several carcinomas has been reported in previous studies. Our study aims to systematically assess the expression pattern of LIPH in breast cancer.
METHODS
Our study explored 2994 breast cancer samples with transcriptome data from the Cancer Genome Atlas (TCGA) and the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) datasets. We systematically evaluated the mRNA expression of LIPH in breast cancer and the overall survival (OS) of patients. The protein expression of LIPH in breast cancer was evaluated with the Human Protein Atlas. We also explored the relationship between LIPH and the immune microenvironment in pan-cancer.
RESULTS
Both mRNA and protein expression LIPH were found to be upregulated in breast cancer tumors. The overall survival rate of patients with high LIPH expression was lower than those of patients with low LIPH expression in both the TCGA dataset (p=0.0067) and METABRIC dataset (p<0.0001). Outcomes of the multivariate analysis found that the level of LIPH expression was an independent prognostic factor in both TCGA (p=0.001) and METABRIC (p=0.019) databases. The outcomes of the univariate analysis showed that LIPH was an important prognostic factor (p=0.01 in TCGA dataset, p=0.001 in METABRIC dataset). In the TCGA dataset, outcomes showed that LIPH expression was negatively correlated with the AJCC (American Joint Committee on Cancer) stage (p=2.3e-05) and triple-negative breast cancer (TNBC) tissues (p=3.1e-10). High LIPH expression showed lower OS in the TNBC subtype (P=0.011).
CONCLUSION
Compared to normal tissues, the expression of LIPH was higher in breast cancer tissues in both mRNA and protein levels. This study showed that the high level of LIPH expression might be related to the worse prognosis of breast cancer.
背景
脂肪酶成员H（LIPH）是哺乳动物甘油三酯脂肪酶家族的一个新成员，定位于人类染色体3q27 - q28。此前的研究报道了新的癌症相关基因LIPH在几种癌症中的重要性。我们的研究旨在系统评估LIPH在乳腺癌中的表达模式。
方法
我们的研究利用来自癌症基因组图谱（TCGA）和国际乳腺癌分子分类联盟（METABRIC）数据集的转录组数据，对2994例乳腺癌样本进行了探索。我们系统评估了LIPH在乳腺癌中的mRNA表达以及患者的总生存期（OS）。利用人类蛋白质图谱评估了LIPH在乳腺癌中的蛋白质表达。我们还探讨了LIPH与泛癌免疫微环境之间的关系。
结果
在乳腺癌肿瘤中发现LIPH的mRNA和蛋白质表达均上调。在TCGA数据集（p = 0.0067）和METABRIC数据集（p < 0.0001）中，LIPH高表达患者的总生存率均低于LIPH低表达患者。多变量分析结果发现，LIPH表达水平在TCGA（p = 0.001）和METABRIC（p = 0.019）数据库中均为独立的预后因素。单变量分析结果显示，LIPH是一个重要的预后因素（在TCGA数据集中p = 0.01，在METABRIC数据集中p = 0.001）。在TCGA数据集中，结果显示LIPH表达与美国癌症联合委员会（AJCC）分期（p = 2.3e - 05）和三阴性乳腺癌（TNBC）组织（p = 3.1e - 10）呈负相关。在TNBC亚型中，LIPH高表达显示出较低的总生存期（P = 0.011）。
结论
与正常组织相比，LIPH在乳腺癌组织中的mRNA和蛋白质水平表达均较高。本研究表明，LIPH高表达可能与乳腺癌预后较差有关。
Zotero 插件