Tosuwan Jidapa, Hunprasit Vachira, Surachetpong Sirilak Disatian
Department of Veterinary Medicine, Faculty of Veterinary Science, Chulalongkorn University, Bangkok Thailand.
Int J Vet Sci Med. 2021 Oct 26;9(1):44-51. doi: 10.1080/23144599.2021.1982335. eCollection 2021.
Feline arterial thromboembolism (ATE) is a condition with a high mortality rate. Acid-base abnormalities may be beneficial to the prognosis of cats with ATE. Venous blood gas and electrolytes data on the first day of ATE presentation of 47 cats with ATE were retrospectively reviewed and analysed. The Cox and logistic regression were analysed to evaluate the relationship between acid-base parameters and death. The most common venous acid-base disorder was simple metabolic acidosis. Age, body weight, and partial venous pressure of carbon dioxide (PvCO2) differed between the dead and alive groups within 7 days of the onset of ATE presentation ( < 0.05). Cox-regression showed that increasing age (HR=1.175 [95% CI: 1.027-1.343], = 0.019), increasing PvCO2 (HR=1.066 [95% CI: 1.010-1.125], = 0.021) and PvCO2 more than 34 mmHg (HR=7.878 [95% CI: 1.036- 59.915], = 0.046) were associated with increased hazard of death. Multivariable logistic regression showed that age > 5 years (OR=9.030, 95% CI: 1.258- 64.823; =0.029), and PvCO2 > 34 mmHg (OR=21.764, 95% CI: 1.747-271.141; =0.017) were associated with an increased risk of death, while concomitant administration of enoxaparin with clopidogrel (OR=0.111, 95% CI: 0.015-0.795; =0.029) were associated with a decreased risk of death within 7 days of the onset of ATE presentation. This study demonstrated the power of venous blood gas analysis which may be used as prognostic indicators for cats with ATE.
猫动脉血栓栓塞症（ATE）是一种死亡率很高的疾病。酸碱异常可能对患有ATE的猫的预后有益。回顾性分析了47只患有ATE的猫在出现ATE第一天的静脉血气和电解质数据。采用Cox回归和逻辑回归分析来评估酸碱参数与死亡之间的关系。最常见的静脉酸碱紊乱是单纯代谢性酸中毒。在出现ATE后7天内，死亡组和存活组之间的年龄、体重和静脉二氧化碳分压（PvCO2）存在差异（P<0.05）。Cox回归显示，年龄增加（HR=1.175[95%CI：1.027-1.343]，P=0.019）、PvCO2升高（HR=1.066[95%CI：1.010-1.125]，P=0.021）以及PvCO2超过34mmHg（HR=7.878[95%CI：1.036-59.915]，P=0.046）与死亡风险增加相关。多变量逻辑回归显示，年龄>5岁（OR=9.030，95%CI：1.258-64.823；P=0.029）和PvCO2>34mmHg（OR=21.764，95%CI：1.747-271.141；P=0.017）与死亡风险增加相关，而在出现ATE后7天内，依诺肝素与氯吡格雷联合使用（OR=0.111，95%CI：0.015-0.795；P=0.029）与死亡风险降低相关。本研究证明了静脉血气分析的作用，其可作为患有ATE的猫的预后指标。
