Hu S L, Fultz P N, McClure H M, Eichberg J W, Thomas E K, Zarling J, Singhal M C, Kosowski S G, Swenson R B, Anderson D C
Nature. 1987;328(6132):721-3. doi: 10.1038/328721a0.
Acquired immunodeficiency syndrome (AIDS) is caused by human immunodeficiency virus (HIV) and is now recognized as a worldwide epidemic for which there is no cure or vaccine. Chimpanzees are the only other animals that can be infected by HIV, and therefore the chimpanzee-HIV model system is useful for testing potential HIV vaccines. However, with one exception, there have been no reports of clinical manifestations of AIDS in chimpanzees. We report here results of an HIV vaccine trial in which nine chimpanzees were first immunized with either a recombinant vaccinia virus expressing the envelope glycoproteins of HIV strain LAV-1 (v-env5) or a control recombinant vaccinia virus and were then challenged with a high or low dose of LAV-1. Although HIV-specific antibody and T-cell responses were elicited by immunization, virus was isolated from lymphocytes of all challenged chimpanzees, indicating that immunization did not prevent infection by HIV. Among the animals that received a higher dose of LAV-1, one of two control chimpanzees, but none of the four v-env5-immunized chimpanzees developed substantial and persistent lymphadenopathy.
获得性免疫缺陷综合征（艾滋病）由人类免疫缺陷病毒（HIV）引起，目前已被公认为一种全球流行且无法治愈、也没有疫苗的疾病。黑猩猩是唯一能被HIV感染的其他动物，因此黑猩猩-HIV模型系统对于测试潜在的HIV疫苗很有用。然而，除了一个例外，尚未有关于黑猩猩出现艾滋病临床表现的报道。我们在此报告一项HIV疫苗试验的结果，在该试验中，9只黑猩猩首先用表达HIV-1株LAV-1包膜糖蛋白的重组痘苗病毒（v-env5）或对照重组痘苗病毒进行免疫，然后用高剂量或低剂量的LAV-1进行攻击。尽管免疫引发了HIV特异性抗体和T细胞反应，但从所有接受攻击的黑猩猩的淋巴细胞中都分离出了病毒，这表明免疫并不能预防HIV感染。在接受较高剂量LAV-1的动物中，两只对照黑猩猩中有一只出现了明显且持续的淋巴结病，而四只接受v-env5免疫的黑猩猩中没有一只出现这种情况。
