Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, Leuven, Belgium; VIB-KU Leuven Center for Microbiology, Leuven, Belgium.
Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, Leuven, Belgium; VIB-KU Leuven Center for Microbiology, Leuven, Belgium.
Trends Pharmacol Sci. 2022 Jan;43(1):69-79. doi: 10.1016/j.tips.2021.10.003. Epub 2021 Oct 29.
To treat infections caused by Candida albicans, azoles, polyenes, and echinocandins are used. However, resistance occurs against all three, so there is an urgent need for new antifungal drugs with a novel mode of action. Recently, it became clear that central metabolism plays an important role in the virulence of C. albicans. Glycolysis is, for example, upregulated during virulence conditions, whereas the glyoxylate cycle is important upon phagocytosis by host immune cells. These findings indicate that C. albicans adapts its metabolism to the environment for maximal virulence. In this review, we provide an overview of the potency of different central metabolic pathways and their key enzymes as potential antifungal drug targets.
治疗由白色念珠菌引起的感染时，会使用唑类、多烯类和棘白菌素类药物。然而，这三类药物均会出现耐药性，因此急需具有新型作用机制的新型抗真菌药物。最近，人们清楚地认识到，中心代谢在白色念珠菌的毒力中起着重要作用。例如，在毒力条件下，糖酵解被上调，而乙醛酸循环在被宿主免疫细胞吞噬时很重要。这些发现表明，白色念珠菌会根据环境调整其代谢以达到最大毒力。在这篇综述中，我们概述了不同中心代谢途径及其关键酶的效力，作为潜在的抗真菌药物靶点。
