Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China; Guangdong Province Key Laboratory of Arrhythmia and Electrophysiology, Guangzhou, China; Guangzhou Key Laboratory of Molecular Mechanism and Translation in Major Cardiovascular Disease, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.
J Affect Disord. 2022 Feb 1;298(Pt A):337-344. doi: 10.1016/j.jad.2021.10.042. Epub 2021 Oct 29.
Levels of inflammatory markers are elevated in patients with psychological disorders. However, anti-psychological drugs have an effect on proinflammatory cytokine production and disturb their relationship. Limited evidence focuses on the inflammatory marker profile of psychological status before treatment. This study aimed to investigate the inflammatory biomarker profiles of psychological treatment-naive individuals.
We included 790 psychological treatment-naive individuals from a longitudinal cohort study of Midlife in the United States (MIDUS). Symptoms of depression, anxiety, and stress were assessed by the Center for Epidemiologic Studies Depression Scale (CES-D) subscales, the Social Anxiety Scale (STAI), and Liebowitz Social Anxiety Scale (LSAS), the Perceived Stress Scale (PSS), respectively.
Spearman correlation analysis showed that a higher CESD total score was correlated with higher CRP (p=0.009), IL-6 (p=0.007), fibrinogen (p=0.036), E-selectin (p=0.018), ICAM-1 (p=0.013), and IL-8 (p=0.05) levels. Multivariate linear regression analysis showed that the CESD total score was positively associated with the levels of IL-6 (p=0.024) after adjustments. Moreover, the perceived stress score (PSS) was negatively associated with the levels of IL-8 (p=0.025). However, these associations were not significant after multiple testing (p=0.088, 0.091, respectively).
The casual relationship cannot be drawn due to the cross-sectional design CONCLUSION: Overall, our results suggested IL-6 and IL-8 might play a important role in the pathogenesis of psychological disorder. Larger and longitude studies are needed to confirm our results.
患有心理障碍的患者体内炎症标志物水平升高。然而，抗心理药物会影响促炎细胞因子的产生并扰乱它们之间的关系。有限的证据集中在治疗前心理状态的炎症标志物特征上。本研究旨在调查心理治疗初治个体的炎症生物标志物特征。
我们纳入了来自美国中年纵向队列研究（MIDUS）的 790 名心理治疗初治个体。抑郁、焦虑和压力症状分别采用流行病学研究中心抑郁量表（CES-D）子量表、社交焦虑量表（STAI）和利伯维茨社交焦虑量表（LSAS）、感知压力量表（PSS）进行评估。
Spearman 相关分析显示，CES-D 总分越高与 CRP（p=0.009）、IL-6（p=0.007）、纤维蛋白原（p=0.036）、E-选择素（p=0.018）、ICAM-1（p=0.013）和 IL-8（p=0.05）水平升高相关。多变量线性回归分析显示，在调整后，CES-D 总分与 IL-6 水平呈正相关（p=0.024）。此外，感知压力评分（PSS）与 IL-8 水平呈负相关（p=0.025）。然而，在多次测试后，这些关联并不显著（p=0.088、0.091）。
由于横断面设计，无法得出因果关系。
总体而言，我们的结果表明 IL-6 和 IL-8 可能在心理障碍的发病机制中起重要作用。需要更大规模和更长时间的研究来证实我们的结果。
