Wang Dong, Li Haijin, Liu Yansong, Li Hong, Liu Yangyang, Hou Lijun
Department of Geriatric Psychiatry, Suzhou Mental Health Center, Suzhou Guangji Hospital, the Affiliated Guangji Hospital of Soochow University, Suzhou, China.
Department of Psychiatry, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Psicol Reflex Crit. 2025 Jan 6;38(1):3. doi: 10.1186/s41155-024-00335-w.
Limited research has been conducted on the relationship between inflammatory markers and psychological status in medical staff fighting COVID-19.
This article examines the psychological and inflammatory conditions of medical personnel working on the front lines of the battle against COVID-19.
A total of 102 clinical staff members were included in this study. All subjects received the Symptom Checklist-90 questionnaire (SCL-90) and Posttraumatic Stress Disorder Checklist-Civilian questionnaires for assessing different mental symptoms. The levels of various inflammatory markers, including IL-1β, IL-2, IL-6, IL-8, TNF-a, and IFN-γ, along with GDNF, were evaluated.
Spearman correlation analysis showed that the levels of IL-6 were positively associated with the anxiety score (Spearman's rho = .230, p = .021), obsessive-compulsive symptoms (Spearman's rho = .201, p = .042). The levels of IL-8 were negatively associated with the anxiety score (Spearman's rho = -.223, p = .028), obsessive-compulsive symptoms (Spearman's rho = -.252, p = .012), hyperarousal (Spearman's rho = -.221, p = .028). The levels of TNF-α were positively associated with the anxiety score (Spearman's rho = .201, p = .045), obsessive-compulsive symptoms (Spearman's rho = .222, p = .035).
Generally, our results suggested that IL-6, IL-8 and TNF-α might play a role in the development of psychological symptoms among medical staff.
关于抗击新冠疫情医护人员炎症标志物与心理状态之间的关系，相关研究有限。
本文研究抗击新冠疫情一线医护人员的心理及炎症状况。
本研究共纳入102名临床工作人员。所有受试者均接受症状自评量表（SCL - 90）和创伤后应激障碍检查表（平民版），以评估不同的心理症状。评估包括白细胞介素 - 1β、白细胞介素 - 2、白细胞介素 - 6、白细胞介素 - 8、肿瘤坏死因子 - α、干扰素 - γ以及胶质细胞源性神经营养因子（GDNF）等多种炎症标志物的水平。
Spearman相关性分析显示，白细胞介素 - 6水平与焦虑评分呈正相关（Spearman相关系数ρ = 0.230，p = 0.021），与强迫症状呈正相关（Spearman相关系数ρ = 0.201，p = 0.042）。白细胞介素 - 8水平与焦虑评分呈负相关（Spearman相关系数ρ = - 0.223，p = 0.028），与强迫症状呈负相关（Spearman相关系数ρ = - 0.252，p = 0.012），与过度警觉呈负相关（Spearman相关系数ρ = - 0.221，p = 0.028）。肿瘤坏死因子 - α水平与焦虑评分呈正相关（Spearman相关系数ρ = 0.201，p = 0.045），与强迫症状呈正相关（Spearman相关系数ρ = 0.222，p = 0.035）。
总体而言，我们的结果表明白细胞介素 - 6、白细胞介素 - 8和肿瘤坏死因子 - α可能在医护人员心理症状的发生发展中起作用。
