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儿童会从睡衣中吸收三(2-氯丙基)磷酸酯阻燃剂:尿液中含有致突变代谢物2,3-二溴丙醇。

Children absorb tris-BP flame retardant from sleepwear: urine contains the mutagenic metabolite, 2,3-dibromopropanol.

作者信息

Blum A, Gold M D, Ames B N, Jones F R, Hett E A, Dougherty R C, Horning E C, Dzidic I, Carroll D I, Stillwell R N, Thenot J P

出版信息

Science. 1978 Sep 15;201(4360):1020-3. doi: 10.1126/science.684422.

DOI:10.1126/science.684422
PMID:684422
Abstract

The flame retardant, tris(2,3-dibromopropyl)phosphate (tris-BP), which is a mutagen and causes cancer and sterility in animals is absorbed from fabric by people. 2,3-Dibromopropanol, a metboloite of tris-BP and a mutagen itself, has been found in the urine samples of ten children who were wearing or who had worn tris-BP-treated sleepwear. Eight of these children were wearing well-washed sleepwear and the possibility of absorption of tris-BP from well-washed sleepwear discussed. 2,3-Dibromopropanol was not found in the urines of one child and one adult who had never worn tris-BP-treated garments.

摘要

阻燃剂磷酸三(2,3 - 二溴丙基)酯(Tris - BP)是一种诱变剂,可导致动物患癌症和不育,人们会从织物中吸收这种物质。2,3 - 二溴丙醇是Tris - BP的一种代谢产物,其本身也是一种诱变剂,在10名穿着或曾穿着经Tris - BP处理的睡衣的儿童的尿液样本中被发现。其中8名儿童穿着洗得很干净的睡衣,探讨了从洗得很干净的睡衣中吸收Tris - BP的可能性。在一名从未穿过经Tris - BP处理的衣物的儿童和一名成年人的尿液中未发现2,3 - 二溴丙醇。

相似文献

1
Children absorb tris-BP flame retardant from sleepwear: urine contains the mutagenic metabolite, 2,3-dibromopropanol.儿童会从睡衣中吸收三(2-氯丙基)磷酸酯阻燃剂:尿液中含有致突变代谢物2,3-二溴丙醇。
Science. 1978 Sep 15;201(4360):1020-3. doi: 10.1126/science.684422.
2
Studies of possible absorption of a flame retardant from treated fabrics worn by rats and humans.
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Another flame retardant, tris-(1,3-dichloro-2-propyl)-phosphate, and its expected metabolites are mutagens.另一种阻燃剂三(1,3 - 二氯 - 2 - 丙基)磷酸酯及其预期代谢产物具有致突变性。
Science. 1978 May 19;200(4343):785-7. doi: 10.1126/science.347576.
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Percutaneous absorption of radiolabeled TRIS from flame-retarded fabric.放射性标记的三羟甲基氨基甲烷从阻燃织物的经皮吸收
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Determination of 2,3-dibromopropanol in air.
Am Ind Hyg Assoc J. 1987 Sep;48(9):809-13. doi: 10.1080/15298668791385615.
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Activation mechanism of tris(2,3-dibromopropyl)phosphate to the potent mutagen, 2-bromoacrolein.磷酸三(2,3-二溴丙基)酯向强效诱变剂2-溴丙烯醛的活化机制。
Biochem Biophys Res Commun. 1984 May 31;121(1):213-9. doi: 10.1016/0006-291x(84)90709-5.
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Metabolism, distribution, and excretion of the flame retardant, tris(2,3-dibromopropyl) phosphate (tris-bp) in the rat: identification of mutagenic and nephrotoxic metabolites.大鼠体内阻燃剂磷酸三(2,3 - 二溴丙基)酯(tris - bp)的代谢、分布及排泄:诱变和肾毒性代谢物的鉴定
Toxicol Appl Pharmacol. 1982 Mar 30;63(1):105-19. doi: 10.1016/0041-008x(82)90030-8.
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Lack of mammalian mutagenicity of the potent bacterial mutagen tris(2,3-dibromopropyl) phosphate and its metabolite 2-bromoacrolein.
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Metabolism in vitro of tris(2,3-dibromopropyl)-phosphate: oxidative debromination and bis(2,3-dibromopropyl)phosphate formation as correlates of mutagenicity and covalent protein binding.磷酸三(2,3-二溴丙基)酯的体外代谢:氧化脱溴及双(2,3-二溴丙基)磷酸酯的形成与致突变性和共价蛋白结合的关系
Biochem Pharmacol. 1984 Dec 15;33(24):4017-23. doi: 10.1016/0006-2952(84)90015-7.
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Mutagenicity of derivatives of the flame retardant tris(2,3-dibromopropyl) phosphate: halogenated propanols.阻燃剂磷酸三(2,3-二溴丙基)酯的衍生物的致突变性:卤代丙醇
Mutat Res. 1978 Jul;57(3):381-4. doi: 10.1016/0027-5107(78)90222-1.

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