Laboratories of Neuroimmunology, Department of Symptom Research, Division of Internal Medicine, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Sci Transl Med. 2021 Nov 10;13(619):eabj7152. doi: 10.1126/scitranslmed.abj7152.
The immune system and the peripheral sensory nervous system communicate through hardwired and humoral routes using shared mediators and receptors. On the basis of studies on pain sensitivity in rodents, the immune system can be viewed as both friend and foe. T cells and macrophages enhance pain via proinflammatory mediators and promote pain resolution via anti-inflammatory mediators and endogenous opioids.
免疫系统和外周感觉神经系统通过使用共享介质和受体的硬连线和体液途径进行通信。基于对啮齿动物疼痛敏感性的研究，可以将免疫系统视为既是朋友又是敌人。T 细胞和巨噬细胞通过促炎介质增强疼痛，并通过抗炎介质和内源性阿片类物质促进疼痛缓解。
