Biosynthesized nanosilver as anti-oxidant, anti-apoptotic and anti-inflammatory agent against infection in the mouse liver.

In recent years, the use of plant-mediated nanoparticle synthesis to combat infectious diseases has become increasingly significant. Malaria is one of the world's most infectious diseases caused by species. The antioxidant, anti-apoptotic, and anti-inflammatory properties of nanosilver biosynthesized from leaf extracts (NS) against infection of the mouse liver were investigated in this research. Male mice were infected with infected erythrocytes then treated with NS for 7 days. The parasitemia was suppressed by approximately 24, 28, 47 and 75% on days 4, 5, 6 and 7 postinfection, respectively after treatment of mice with NS. Also, NS was able to regulate the leucocytes count and the I and -mRNA expression in mice. Ns could increase the antioxidant activity in liver of mice and was able to regulate the apoptotic genes, and . We showed that NS has antioxidant, anti-apoptotic, and anti-inflammatory properties when it was used to treat the livers of mice infected with .