使用序列化的多点基因定位。I. 通用方法。
Multipoint gene mapping using seriation. I. General methods.
作者信息
Buetow K H, Chakravarti A
出版信息
Am J Hum Genet. 1987 Aug;41(2):180-8.
Abstract
Initial and accurate inference of locus order and estimates of interlocus distances and interference can be obtained using seriation techniques. The analysis requires a matrix of recombination values that can be estimated by standard pairwise linkage analysis. This allows combination of results from individual investigators without reanalysis of basic pedigree material. Seriation can be performed without the use of a computer.
摘要
使用序列化技术可以获得基因座顺序的初步准确推断、基因座间距离估计以及干涉估计。该分析需要一个重组值矩阵，可通过标准的成对连锁分析来估计。这使得可以合并各个研究者的结果，而无需重新分析基本的家系材料。序列化可以不用计算机进行。
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