Sun Jintao, Li Yihan, Zhang Ke, Sun Yulei, Wang Yingfan, Miao Ailiang, Xiang Jing, Wang Xiaoshan
Department of Neurology, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.
Division of Neurology, MEG Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Front Neurol. 2021 Oct 25;12:744749. doi: 10.3389/fneur.2021.744749. eCollection 2021.
Our aim was to investigate the dynamics of functional connectivity (FC) networks during seizure termination in patients with childhood absence epilepsy (CAE) using magnetoencephalography (MEG) and graph theory (GT) analysis. MEG data were recorded from 22 drug-naïve patients diagnosed with CAE. FC analysis was performed to evaluate the FC networks in seven frequency bands of the MEG data. GT analysis was used to assess the topological properties of FC networks in different frequency bands. The patterns of FC networks involving the frontal cortex were altered significantly during seizure termination compared with those during the ictal period. Changes in the topological parameters of FC networks were observed in specific frequency bands during seizure termination compared with those in the ictal period. In addition, the connectivity strength at 250-500 Hz during the ictal period was negatively correlated with seizure frequency. FC networks associated with the frontal cortex were involved in the termination of absence seizures. The topological properties of FC networks in different frequency bands could be used as new biomarkers to characterize the dynamics of FC networks related to seizure termination.
我们的目的是使用脑磁图（MEG）和图论（GT）分析，研究儿童失神癫痫（CAE）患者癫痫发作终止期间功能连接（FC）网络的动态变化。记录了22例未经药物治疗、诊断为CAE的患者的MEG数据。进行FC分析以评估MEG数据七个频段中的FC网络。GT分析用于评估不同频段FC网络的拓扑特性。与发作期相比，癫痫发作终止期间涉及额叶皮质的FC网络模式发生了显著改变。与发作期相比，在癫痫发作终止期间的特定频段观察到FC网络拓扑参数的变化。此外，发作期250 - 500 Hz的连接强度与癫痫发作频率呈负相关。与额叶皮质相关的FC网络参与了失神发作的终止。不同频段FC网络的拓扑特性可作为新的生物标志物，以表征与癫痫发作终止相关的FC网络动态变化。
