Saboo Banshi, Agarwal Sanjay, Gupta Sunil, Makkar Brij, Panneerselvam A, Sahoo Abhay Kumar, Ramchandani G D, Das Sambit, Erande Suhas, Kadam Yogesh, Abhyankar Mahesh V, Revankar Santosh
Department of Diabetology, Diabetes Care and Hormone Clinic, Ambawadi, Ahmedabad, Gujarat, India.
Department of Internal Medicine, Dr. Sanjay Agarwal's Aegle Clinic, City, Pune, Maharashtra, India.
J Family Med Prim Care. 2021 Sep;10(9):3444-3452. doi: 10.4103/jfmpc.jfmpc_2010_20. Epub 2021 Sep 30.
To assess the clinical characteristics, risk factors, and comorbidities associated with type 2 diabetes mellitus (T2DM) in young adult patients.
This is a retrospective, multicentric real-world study that included young adults (18-45 years) with T2DM. Primary information including demographics, medical and family history, biochemical measures (pre-and post-prandial blood glucose levels, glycosylated hemoglobin [HbA1c] and blood pressure, and lipid parameters) smoking and drinking habits were collected retrospectively from the medical records of the respective hospitals/clinics. Data were analyzed using descriptive and appropriate comparative statistics.
A total of 22,921 patients from 623 sites were included. The median age was 37.0 years and the majority were men (61.6%). The proportion of patients from the age group >35-≤45 years was 62.7%. Among all patients, 46.9% had only T2DM; however, 53.1% of patients had T2DM with other comorbidities (T2DM with hypertension, dyslipidemia, and both). The majority of patients had elevated body mass index (BMI) (overweight, 46.6%; and obese, 22.9%). Family history of T2DM (68.1%) was most common in overall population. Sedentary lifestyle (63.1%), alcohol consumption (38.9%), and regular smoking (23.1%) were the most common associations in patients with T2DM with dyslipidemia and hypertension. Uncontrolled HbA1c level (≥7%) were observed in 79.2% of patients. The level of HbA1c was significantly increased with the duration of T2DM and sedentary lifestyle ( < 0.001).
Higher BMI, family history of T2DM, sedentary lifestyle, alcohol consumption, and smoking were the most common risk facors, while hypertension and dyslipidemia were the most prevalent comorbidities associated with T2DM in young Indian adults.
评估年轻成年2型糖尿病（T2DM）患者的临床特征、危险因素及合并症。
这是一项回顾性、多中心的真实世界研究，纳入了18至45岁的T2DM年轻成年人。从各医院/诊所的病历中回顾性收集包括人口统计学、病史和家族史、生化指标（餐前和餐后血糖水平、糖化血红蛋白[HbA1c]、血压和血脂参数）、吸烟和饮酒习惯等主要信息。使用描述性和适当的比较统计方法进行数据分析。
共纳入来自623个研究点的22921例患者。中位年龄为37.0岁，大多数为男性（61.6%）。年龄在>35至≤45岁组的患者比例为62.7%。在所有患者中，46.9%仅患有T2DM；然而，53.1%的患者患有T2DM合并其他合并症（T2DM合并高血压、血脂异常或两者皆有）。大多数患者体重指数（BMI）升高（超重，46.6%；肥胖，22.9%）。T2DM家族史（68.1%）在总体人群中最为常见。久坐不动的生活方式（63.1%）、饮酒（38.9%）和经常吸烟（23.1%）是T2DM合并血脂异常和高血压患者中最常见的关联因素。79.2%的患者糖化血红蛋白（HbA1c）水平未得到控制（≥7%）。HbA1c水平随T2DM病程和久坐不动的生活方式显著升高（<0.001）。
较高的BMI、T2DM家族史、久坐不动的生活方式、饮酒和吸烟是最常见的危险因素，而高血压和血脂异常是印度年轻成年人中与T2DM相关的最常见合并症。
