Tripathi Pramod, Kadam Nidhi, Kathrikolly Thejas, Tiwari Diptika, Vyawahare Anagha, Sharma Baby, Ganla Malhar, Saboo Banshi
Department of Research, Freedom from Diabetes Research Foundation, 'Parth', Ghodke Chowk, Prabhat Road, Pune, Maharashtra, 411004, India.
Freedom from Diabetes Clinic, 'Parth', Ghodke Chowk, Prabhat Road, Pune, Maharashtra, 411004, India.
Sci Rep. 2025 Mar 25;15(1):10275. doi: 10.1038/s41598-025-94694-8.
Assessing the clinical and biochemical profiles of patients with type-2 diabetes (T2D) is vital for understanding the disease characteristics and improving disease management. This study aimed to assess the profiles of adults (> 18 years old) with T2D enrolled in a one-year diabetes management program in Pune, India. This cross-sectional study retrospectively analyzed 18,950 records from the Freedom from Diabetes Clinic, between November 2015 and June 2023. Baseline sociodemographic, biochemical, and anthropometric parameters were extracted from electronic medical records and analyzed using descriptive statistical methods. A gender-wise comparison was performed for the biochemical and anthropometric measurements. Poor glycemic control (glycated hemoglobin [HbA1c] ≥ 7%) was reported by 70.0% of the patients at baseline, despite the majority (80.2%) being on glucose lowering medications. The prevalence of overweight (body mass index [BMI] 23.0-24.9 kg/m) and obesity (BMI ≥ 25 kg/m) was 21.5% and 57.2%, respectively. Hypertension and hypercholesterolemia were reported in 56.8% and 25.7% of the patients, respectively. A significant association was observed between comorbidities such as hypertension, overweight/obesity, and poor glycemic control (p < 0.05). Additionally, significant gender-wise differences were observed in the clinical parameters, including homeostatic model assessment of insulin resistance, fasting insulin, and micronutrients (p < 0.05). This study highlights the high prevalence of poor glycemic control, overweight/obesity, and comorbidities among T2D patients enrolled in a one-year diabetes management program in India. Gender-specific differences emphasize the need for tailored management approaches. These findings underscore the importance of comprehensive lifestyle interventions to improve glycemic control, address comorbidities, and reduce complication risks in the Indian population with T2D.
评估2型糖尿病（T2D）患者的临床和生化特征对于了解疾病特点和改善疾病管理至关重要。本研究旨在评估印度浦那参加为期一年糖尿病管理项目的成年（>18岁）T2D患者的特征。这项横断面研究回顾性分析了2015年11月至2023年6月期间糖尿病自由诊所的18950份记录。从电子病历中提取基线社会人口统计学、生化和人体测量参数，并使用描述性统计方法进行分析。对生化和人体测量指标进行了性别差异比较。尽管大多数患者（80.2%）正在服用降糖药物，但在基线时仍有70.0%的患者血糖控制不佳（糖化血红蛋白[HbA1c]≥7%）。超重（体重指数[BMI]23.0 - 24.9kg/m²）和肥胖（BMI≥25kg/m²）的患病率分别为21.5%和57.2%。分别有56.8%和25.7%的患者报告患有高血压和高胆固醇血症。观察到高血压、超重/肥胖等合并症与血糖控制不佳之间存在显著关联（p<0.05）。此外，在临床参数方面观察到显著的性别差异，包括胰岛素抵抗的稳态模型评估、空腹胰岛素和微量营养素（p<0.05）。本研究强调了在印度参加为期一年糖尿病管理项目的T2D患者中，血糖控制不佳、超重/肥胖和合并症的高患病率。性别特异性差异强调了需要采取针对性的管理方法。这些发现强调了全面生活方式干预对于改善印度T2D人群血糖控制、解决合并症和降低并发症风险的重要性。
