Yazdiniapour Zeinab, Yegdaneh Afsaneh, Akbari Soudeh
Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2021 Sep 29;10:23. doi: 10.4103/abr.abr_1_21. eCollection 2021.
Podl. is a green aromatic perennial shrub that belongs to the family and it grows widely in central deserts and south-eastern mountains of Iran such as Taftan Mountain in Sistan and Baluchestan Province. species have been used traditionally as a remedy for various feverous diseases, including malaria, treatment of colds, infections, parasites, inflammations of the liver, as well as dyspepsia, diabetes, hypertension, and so many other conditions.
Air-dried extraction from all parts of the plant was done using different organic solvents. The methanolic extract was selected for isolation of flavonoids, using thin-layer chromatography. The chemical structures of the isolated compounds were determined based on analysis of mass and nuclear magnetic resonance spectra.
Two flavone aglycones were isolated and identified for the first time from this plant's methanolic extract, including 5,7-dihydroxy-3',4',6-trimethoxyflavone (eupatilin) and 5,7,3'-Trihydroxy-6,4',5'-trimethoxyflavone.
Eupatilin is known for its anticancer, antioxidant, and anti-inflammatory activities. In future researches on , as a rich source of these flavone compounds, it is wise to investigate for the proven eupatilin's biological activities that have been mentioned.
Podl. 是一种绿色芳香多年生灌木，属于[具体科名未给出]科，广泛生长于伊朗中部沙漠和东南部山区，如锡斯坦-俾路支斯坦省的塔夫坦山。该物种传统上被用作治疗各种发热性疾病的药物，包括疟疾、感冒、感染、寄生虫、肝脏炎症，以及消化不良、糖尿病、高血压等许多其他病症。
使用不同有机溶剂对植物各部位进行风干提取。采用薄层色谱法从甲醇提取物中分离黄酮类化合物。基于质谱和核磁共振光谱分析确定分离出的化合物的化学结构。
首次从该植物的甲醇提取物中分离并鉴定出两种黄酮苷元，包括5,7 - 二羟基 - 3',4',6 - 三甲氧基黄酮（尤帕梯林）和5,7,3'- 三羟基 - 6,4',5'- 三甲氧基黄酮。
尤帕梯林以其抗癌、抗氧化和抗炎活性而闻名。在未来对Podl. 的研究中，作为这些黄酮类化合物的丰富来源，明智的做法是研究已提及的经证实的尤帕梯林的生物活性。
