Department of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, South Korea.
Department of Immunology, School of Medicine, Keimyung University, 2800 Dalgubeoldaero, Dalseo-Gu, Daegu 704-701, South Korea.
Biomed Pharmacother. 2018 Jul;103:135-139. doi: 10.1016/j.biopha.2018.03.073. Epub 2018 Apr 24.
Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone) is a flavonoid compound from Artemisia species that possesses beneficial biological activities such as anti-cancer, anti-oxidation, and anti-inflammatory activities. However, an anti-adipogenic effect has not yet been reported. In this study, we found that eupatilin significantly inhibited the adipogenesis of 3T3-L1 adipocytes. Eupatilin decreased intracellular lipid accumulation and suppressed the expression level of key adipogenic regulators in 3T3-L1 adipocytes, including peroxisome proliferator-activated receptor gamma (PPARγ) and CCAAT-enhancer-binding protein alpha (C/EBPα), in a concentration-dependent manner. These results show that eupatilin significantly inhibits 3T3-L1 cell differentiation and suggest that it has potential as a novel anti-obesity therapy.
柚皮素（5,7-二羟基-3',4',6-三甲氧基黄酮）是一种来自蒿属植物的类黄酮化合物，具有有益的生物活性，如抗癌、抗氧化和抗炎活性。然而，其抗脂肪生成作用尚未见报道。在这项研究中，我们发现柚皮素能显著抑制 3T3-L1 脂肪细胞的脂肪生成。柚皮素以浓度依赖的方式减少了 3T3-L1 脂肪细胞内的脂质积累，并抑制了关键脂肪生成调节剂的表达水平，包括过氧化物酶体增殖物激活受体γ（PPARγ）和 CCAAT 增强子结合蛋白α（C/EBPα）。这些结果表明柚皮素能显著抑制 3T3-L1 细胞分化，并提示其可能成为一种新型的抗肥胖治疗药物。
