Strowitzki T, Wiedemann R, Mempel W, Hepp H
Frauenklinik im Klinikum Grosshadern, Universität München.
Arch Gynecol Obstet. 1989;245(1-4):157-9. doi: 10.1007/BF02417221.
Since 1985, after excluding nonimmunological reasons for habitual abortion, we have been performing an MCL, a cross-match, and an HLA typing in these patients. Those with a low MLC response and a negative cross-match are considered to be immunological aborters. Only three out of 42 examined couples showed a low response and in 21 of 24 tested couples the cross-match was negative. Of 36 patients with a high response, 10 had successful pregnancies; seven of them shared more than two HLA antigens. An immunological treatment is indicated in patients with low response and a negative cross-match. High responders should have another pregnancy without stimulation. HLA typing is without any consequences.
自1985年以来，在排除习惯性流产的非免疫性原因后，我们一直在对这些患者进行混合淋巴细胞培养（MCL）、交叉配型和HLA分型。混合淋巴细胞培养反应低且交叉配型为阴性的患者被视为免疫性流产者。在42对接受检查的夫妇中，只有3对显示反应低，在24对接受检测的夫妇中，有21对交叉配型为阴性。在36例反应高的患者中，有10例成功妊娠；其中7例共享两种以上的HLA抗原。对于反应低且交叉配型为阴性的患者，建议进行免疫治疗。反应高的患者应在无刺激的情况下再次妊娠。HLA分型没有任何不良后果。
