Garner Amy J, Dandridge Oliver W, Amis Andrew A, Cobb Justin P, van Arkel Richard J
MSk Lab, Sir Michael Uren Biomedical Engineering Research Hub, Imperial College London, London, UK.
Biomechanics Group, Mechanical Engineering Department, Imperial College London, London, UK.
Bone Joint Res. 2021 Nov;10(11):723-733. doi: 10.1302/2046-3758.1011.BJR-2021-0151.R1.
Bi-unicondylar arthroplasty (Bi-UKA) is a bone and anterior cruciate ligament (ACL)-preserving alternative to total knee arthroplasty (TKA) when the patellofemoral joint is preserved. The aim of this study is to investigate the clinical outcomes and biomechanics of Bi-UKA.
Bi-UKA subjects (n = 22) were measured on an instrumented treadmill, using standard gait metrics, at top walking speeds. Age-, sex-, and BMI-matched healthy (n = 24) and primary TKA (n = 22) subjects formed control groups. TKA subjects with preoperative patellofemoral or tricompartmental arthritis or ACL dysfunction were excluded. The Oxford Knee Score (OKS) and EuroQol five-dimension questionnaire (EQ-5D) were compared. Bi-UKA, then TKA, were performed on eight fresh frozen cadaveric knees, to investigate knee extensor efficiency under controlled laboratory conditions, using a repeated measures study design.
Bi-UKA walked 20% faster than TKA (Bi-UKA mean top walking speed 6.7 km/h (SD 0.9),TKA 5.6 km/h (SD 0.7), p < 0.001), exhibiting nearer-normal vertical ground reaction forces in maximum weight acceptance and mid-stance, with longer step and stride lengths compared to TKA (p < 0.048). Bi-UKA subjects reported higher OKS (p = 0.004) and EQ-5D (p < 0.001). In vitro, Bi-UKA generated the same extensor moment as native knees at low flexion angles, while reduced extensor moment was measured following TKA (p < 0.003). Conversely, at higher flexion angles, the extensor moment of TKA was normal. Over the full range, the extensor mechanism was more efficient following Bi-UKA than TKA (p < 0.028).
Bi-UKA had more normal gait characteristics and improved patient-reported outcomes, compared to matched TKA subjects. This can, in part, be explained by differences in extensor efficiency. Cite this article: 2021;10(11):723-733.
双髁置换术(Bi-UKA)是在保留髌股关节时,一种保留骨和前交叉韧带(ACL)的全膝关节置换术(TKA)替代方案。本研究旨在调查Bi-UKA的临床疗效和生物力学。
在仪器化跑步机上,以标准步态指标,对Bi-UKA受试者(n = 22)进行最高步行速度测量。年龄、性别和体重指数匹配的健康受试者(n = 24)和初次TKA受试者(n = 22)组成对照组。排除术前有髌股关节炎或三关节间关节炎或ACL功能障碍的TKA受试者。比较牛津膝关节评分(OKS)和欧洲五维健康量表问卷(EQ-5D)。对八个新鲜冷冻尸体膝关节先进行Bi-UKA,然后进行TKA,采用重复测量研究设计,在受控实验室条件下研究膝关节伸肌效率。
Bi-UKA的步行速度比TKA快20%(Bi-UKA的平均最高步行速度为6.7 km/h(标准差0.9),TKA为5.6 km/h(标准差0.7),p < 0.001),在最大承重和步幅中期表现出更接近正常的垂直地面反作用力,与TKA相比步长和步幅更长(p < 0.048)。Bi-UKA受试者报告的OKS(p = 0.004)和EQ-5D(p < 0.001)更高。在体外,Bi-UKA在低屈曲角度时产生的伸肌力矩与天然膝关节相同,而TKA后测量的伸肌力矩降低(p < 0.003)。相反,在较高屈曲角度时,TKA的伸肌力矩正常。在整个范围内,Bi-UKA后的伸肌机制比TKA更有效(p < 0.028)。
与匹配的TKA受试者相比,Bi-UKA具有更正常的步态特征,患者报告的结局得到改善。这部分可以通过伸肌效率的差异来解释。引用本文:2021;10(11):723-733。