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双髁关节置换术:一项生物力学与临床结果研究。

Bi-unicondylar arthroplasty : a biomechanics and clinical outcomes study.

作者信息

Garner Amy J, Dandridge Oliver W, Amis Andrew A, Cobb Justin P, van Arkel Richard J

机构信息

MSk Lab, Sir Michael Uren Biomedical Engineering Research Hub, Imperial College London, London, UK.

Biomechanics Group, Mechanical Engineering Department, Imperial College London, London, UK.

出版信息

Bone Joint Res. 2021 Nov;10(11):723-733. doi: 10.1302/2046-3758.1011.BJR-2021-0151.R1.

Abstract

AIMS

Bi-unicondylar arthroplasty (Bi-UKA) is a bone and anterior cruciate ligament (ACL)-preserving alternative to total knee arthroplasty (TKA) when the patellofemoral joint is preserved. The aim of this study is to investigate the clinical outcomes and biomechanics of Bi-UKA.

METHODS

Bi-UKA subjects (n = 22) were measured on an instrumented treadmill, using standard gait metrics, at top walking speeds. Age-, sex-, and BMI-matched healthy (n = 24) and primary TKA (n = 22) subjects formed control groups. TKA subjects with preoperative patellofemoral or tricompartmental arthritis or ACL dysfunction were excluded. The Oxford Knee Score (OKS) and EuroQol five-dimension questionnaire (EQ-5D) were compared. Bi-UKA, then TKA, were performed on eight fresh frozen cadaveric knees, to investigate knee extensor efficiency under controlled laboratory conditions, using a repeated measures study design.

RESULTS

Bi-UKA walked 20% faster than TKA (Bi-UKA mean top walking speed 6.7 km/h (SD 0.9),TKA 5.6 km/h (SD 0.7), p < 0.001), exhibiting nearer-normal vertical ground reaction forces in maximum weight acceptance and mid-stance, with longer step and stride lengths compared to TKA (p < 0.048). Bi-UKA subjects reported higher OKS (p = 0.004) and EQ-5D (p < 0.001). In vitro, Bi-UKA generated the same extensor moment as native knees at low flexion angles, while reduced extensor moment was measured following TKA (p < 0.003). Conversely, at higher flexion angles, the extensor moment of TKA was normal. Over the full range, the extensor mechanism was more efficient following Bi-UKA than TKA (p < 0.028).

CONCLUSION

Bi-UKA had more normal gait characteristics and improved patient-reported outcomes, compared to matched TKA subjects. This can, in part, be explained by differences in extensor efficiency. Cite this article:  2021;10(11):723-733.

摘要

目的

双髁置换术(Bi-UKA)是在保留髌股关节时,一种保留骨和前交叉韧带(ACL)的全膝关节置换术(TKA)替代方案。本研究旨在调查Bi-UKA的临床疗效和生物力学。

方法

在仪器化跑步机上,以标准步态指标,对Bi-UKA受试者(n = 22)进行最高步行速度测量。年龄、性别和体重指数匹配的健康受试者(n = 24)和初次TKA受试者(n = 22)组成对照组。排除术前有髌股关节炎或三关节间关节炎或ACL功能障碍的TKA受试者。比较牛津膝关节评分(OKS)和欧洲五维健康量表问卷(EQ-5D)。对八个新鲜冷冻尸体膝关节先进行Bi-UKA,然后进行TKA,采用重复测量研究设计,在受控实验室条件下研究膝关节伸肌效率。

结果

Bi-UKA的步行速度比TKA快20%(Bi-UKA的平均最高步行速度为6.7 km/h(标准差0.9),TKA为5.6 km/h(标准差0.7),p < 0.001),在最大承重和步幅中期表现出更接近正常的垂直地面反作用力,与TKA相比步长和步幅更长(p < 0.048)。Bi-UKA受试者报告的OKS(p = 0.004)和EQ-5D(p < 0.001)更高。在体外,Bi-UKA在低屈曲角度时产生的伸肌力矩与天然膝关节相同,而TKA后测量的伸肌力矩降低(p < 0.003)。相反,在较高屈曲角度时,TKA的伸肌力矩正常。在整个范围内,Bi-UKA后的伸肌机制比TKA更有效(p < 0.028)。

结论

与匹配的TKA受试者相比,Bi-UKA具有更正常的步态特征,患者报告的结局得到改善。这部分可以通过伸肌效率的差异来解释。引用本文:2021;10(11):723-733。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52d9/8636181/91ae663b602a/BJR-10-723-g0001.jpg

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