Drugeon H B, Dellamonica P, Caillon J
Pathol Biol (Paris). 1987 May;35(5):495-500.
Six strains of Staphylococcus aureus have been studied using an original method which associate the chessboard's technique to that of bactericidal kinetic's. Associations of pefloxacin and rifampicin, vancomycin and fosfomycin are analysed, and result of each concentration's connection is expressed, at 1.5, 3,5 and 24 h, by a three dimensional representation, which facilitate the phenomenon's dynamic. Interpretation of these diagrams can show the classical phenomena of synergy, addition, indifference and antagonism, and also that of domination of an antibiotic in the association. This one can work, by example, by imposing its bactericidal's speed (vancomycin) or by selecting deficient surviving bacteria (rifampicin). This, the intrinsic and sometimes undesirable characteristics of some antibiotics are not masked by the others antibiotics used in the association. This mechanism must be proved in vivo, but it is sure that during physico-chemical inactivity or during diffusion's deficiency of one of antibiotics, transient relation of concentrations are favorable conditions for domination's expression.
已使用一种将棋盘技术与杀菌动力学技术相结合的独创方法，对六株金黄色葡萄球菌进行了研究。分析了培氟沙星与利福平、万古霉素与磷霉素的联合使用情况，并在1.5、3、5和24小时时，通过三维表示法展示每种浓度组合的结果，这便于呈现该现象的动态变化。对这些图表的解读可显示协同、相加、无作用和拮抗等经典现象，以及联合使用中一种抗生素占主导的现象。例如，这种占主导现象可能通过施加其杀菌速度（万古霉素）或通过选择有缺陷的存活细菌（利福平）来起作用。这样，联合使用中某些抗生素的内在且有时不理想的特性不会被其他抗生素掩盖。这种机制必须在体内得到证实，但可以肯定的是，在其中一种抗生素处于物理化学不活性状态或扩散不足期间，浓度的瞬时关系是占主导现象表达的有利条件。
