Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
Biomarkers of Chronic Diseases, Biochemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
Dis Markers. 2021 Nov 2;2021:4791915. doi: 10.1155/2021/4791915. eCollection 2021.
The role of lipid metabolism disorders in the pathogenesis of T2DM has been recognized. Lipid droplets (LDs) are dynamic organelles that store lipids. Perilipin 3 (PLIN3) is one of the five LD coat proteins that is relatively understudied as compared to other LDs. This study is aimed at determining levels of PLIN3 among adults with varying levels of obesity and insulin resistance to determine metabolic associations of PLIN3. . A total of 280 Saudi adults ( = 127 males; = 153 females) were randomly recruited and divided into three groups according to their body mass index (BMI) and fasting glucose levels: healthy and lean (HL), obese and T2DM (OD), or obese and nondiabetic (OND). Lipid profiles, fasting glucose levels, insulin, and perilipin 3 levels were measured.
Circulating PLIN3 was significantly lower in the OD group [8.3 ng/mL (1.2-22.5; < 0.001)] than the HL group [23.1 ng/mL (6.2-39.1; < 0.001)]. Triglycerides, total cholesterol, glucose, and insulin levels were inversely correlated with PLIN3 in all subjects. Lastly, glucose, insulin, and total cholesterol cumulatively predict circulating levels of PLIN3 by as much as 11% of the variances perceived ( < 0.001).
Circulating PLIN3 is significantly associated with insulin resistance markers and maybe a promising candidate as a protective biomarker for T2DM.
脂质代谢紊乱在 2 型糖尿病发病机制中的作用已得到认可。脂滴（LDs）是储存脂质的动态细胞器。脂滴包被蛋白 3（PLIN3）是 5 种 LD 包膜蛋白之一，与其他 LD 相比，其研究相对较少。本研究旨在确定不同肥胖和胰岛素抵抗程度的成年人中 PLIN3 的水平，以确定 PLIN3 的代谢相关性。共随机招募了 280 名沙特成年人（=127 名男性；=153 名女性），根据其体重指数（BMI）和空腹血糖水平分为三组：健康和消瘦（HL）、肥胖和 2 型糖尿病（OD）或肥胖和非糖尿病（OND）。测量了血脂谱、空腹血糖水平、胰岛素和脂滴包被蛋白 3 水平。结果：OD 组循环 PLIN3 显著低于 HL 组[8.3ng/mL（1.2-22.5；<0.001）]。在所有受试者中，甘油三酯、总胆固醇、血糖和胰岛素水平与 PLIN3 呈负相关。最后，血糖、胰岛素和总胆固醇共同预测循环 PLIN3 水平，可解释 11%的可变性（<0.001）。结论：循环 PLIN3 与胰岛素抵抗标志物显著相关，可能是 2 型糖尿病的有前途的保护生物标志物。
