Itabe Hiroyuki, Yamaguchi Tomohiro, Nimura Satomi, Sasabe Naoko
Division of Biological Chemistry, Department of Molecular Biology, Showa University School of Pharmacy, 1-5-8 Hatanodai, Shinagawa, Tokyo, 142-8555, Japan.
Present address: College of Pharmacy, Kinjo Gakuin University, 2-1723 Omori, Moriyaka-ku, Nagoya, 463-8521, Japan.
Lipids Health Dis. 2017 Apr 28;16(1):83. doi: 10.1186/s12944-017-0473-y.
Intracellular lipid droplets (LDs) are found in a wide variety of cell types and have been recognized as organelles with unique spherical structures. Although LDs are not stable lipid-depots, they are active sites of neutral lipid metabolism, and comprise neutral lipid or cholesterol cores surrounded by phospholipid monolayers containing specialized proteins. However, sizes and protein compositions vary between cell and tissue types. Proteins of the perilipin family have been associated with surfaces of LDs and all carry a conserved 11-mer repeat motif. Accumulating evidence indicates that all perilipins are involved in LD formation and that all play roles in LD function under differing conditions. In this brief review, we summarize current knowledge of the roles of perilipins and lipid metabolizing enzymes in a variety of mammalian cell types.
细胞内脂滴（LDs）存在于多种细胞类型中，已被公认为具有独特球形结构的细胞器。尽管脂滴不是稳定的脂质储存库，但它们是中性脂质代谢的活跃位点，由被含有特定蛋白质的磷脂单层包围的中性脂质或胆固醇核心组成。然而，其大小和蛋白质组成在不同的细胞和组织类型之间有所不同。围脂滴蛋白家族的蛋白质与脂滴表面相关，并且都带有一个保守的11聚体重复基序。越来越多的证据表明，所有围脂滴蛋白都参与脂滴形成，并且在不同条件下都对脂滴功能发挥作用。在这篇简短的综述中，我们总结了目前关于围脂滴蛋白和脂质代谢酶在多种哺乳动物细胞类型中的作用的知识。
