Remadevi Viji, Muraleedharan Parvathy, Sreeja Sreeharshan
Cancer Research Program, Rajiv Gandhi Centre for Biotechnology Thiruvananthapuram, Kerala 695014, India.
Department of Botany, Mount Carmel College Autonomous Bengaluru, Karnataka 560001, India.
Am J Cancer Res. 2021 Oct 15;11(10):4700-4710. eCollection 2021.
The transcription factor FOXO1 regulates cell cycle progression, apoptosis and oxidative stress. Interestingly, numerous studies have implicated their positive role in tumor suppression, angiogenesis and metastasis in oral squamous cell carcinoma (OSCC). Distinct post-transcriptional and post-translational modifications actuate the physiological role of FOXO1 in OSCC. Here, we evaluate the role of FOXO1 proteins in OSCC, their fundamental structure and the major players involved in FOXO1 regulation and how they are Pharmacologically modulated in OSCC. Finally, their role in regulating epithelial-mesenchymal transition (EMT), autophagy, stress tolerance and stemness, which would significantly aid in novel potential oversight for future research and thus developing strategies to prevent or reverse OSCC.
转录因子FOXO1调节细胞周期进程、细胞凋亡和氧化应激。有趣的是，大量研究表明其在口腔鳞状细胞癌（OSCC）的肿瘤抑制、血管生成和转移中发挥积极作用。不同的转录后和翻译后修饰激活了FOXO1在OSCC中的生理作用。在此，我们评估FOXO1蛋白在OSCC中的作用、其基本结构以及参与FOXO1调节的主要因子，以及它们在OSCC中是如何受到药理学调节的。最后，评估它们在调节上皮-间质转化（EMT）、自噬、应激耐受性和干性方面的作用，这将极大地有助于未来研究的新潜在监督，并从而制定预防或逆转OSCC的策略。
