Takagi S, Chow L C, Yamada E M, Brown W E
J Dent Res. 1987 Oct;66(10):1523-6. doi: 10.1177/00220345870660100201.
Application of DCPD-forming solutions has been shown to increase substantially the enamel reactivity toward F. The effectiveness of a variation of this treatment procedure, in which the DCPD-forming solution was replaced by a viscous carboxymethylcellulose gel containing monocalcium phosphate monohydrate (MCPM), was evaluated by use of 12 extracted human molars. The MCPM gel was highly effective in enhancing the F uptake by enamel. The mean F uptakes by teeth treated with MCPM gel, followed by exposure to a F solution, were 3972 (+/- 565), 2383 (+/- 312), and 1751 (+/- 313) ppm, respectively, in the outer 5-, 10-, and 15-microns depths in enamel. These uptakes were 2374, 1273, and 852 ppm more than those of the control teeth. Because the F solution was undersaturated with respect to CaF2, the F incorporated into the enamel was believed to be in apatitic form and not as CaF2. The MCPM gel has advantages over the DCPD-forming solution because (1) much longer gel-tooth contact times can be achieved, and (2) the treatment agent can readily be delivered to specific sites where the tooth needs the protection most.
已证明应用生成磷酸二钙二水合物（DCPD）的溶液可大幅提高牙釉质对氟的反应性。使用12颗拔除的人类磨牙评估了该治疗程序的一种变体的有效性，其中用含有一水磷酸二氢钙（MCPM）的粘性羧甲基纤维素凝胶代替生成DCPD的溶液。MCPM凝胶在增强牙釉质对氟的摄取方面非常有效。在用MCPM凝胶处理后再暴露于氟溶液的牙齿中，在牙釉质外层5微米、10微米和15微米深度处的平均氟摄取量分别为3972（±565）、2383（±312）和1751（±313）ppm。这些摄取量分别比对照牙齿多2374、1273和852 ppm。由于氟溶液相对于氟化钙不饱和，因此认为掺入牙釉质中的氟是以磷灰石形式存在，而不是以氟化钙形式存在。MCPM凝胶比生成DCPD的溶液具有优势，因为（1）可以实现凝胶与牙齿更长的接触时间，并且（2）治疗剂可以很容易地输送到牙齿最需要保护的特定部位。
