The Anti-Colon Cancer Effects of Essential Oil of Through Tumour Vessel Normalisation.

BACKGROUND

Normalising tumour vessels had become a significant research focus in tumour treatment research in recent years. (CR) is an essential plant in traditional Chinese medicine as it promotes blood circulation and removes blood stasis. Similarly, CR improves local blood circulation.

PURPOSE

We explored the anti-colon cancer effects of essential oil from CR (OCR) by investigating its role in normalising tumour vessels. We also provided a basis for research and development into new anti-cancer drugs.

METHODS

We used colon cancer as a research focus to investigate OCR. We established an co-culture model of colon cancer cells and human umbilical vein endothelial cells (HUVEC). We also established an subcutaneous implant colon cancer model in nude mice. These studies allowed us to evaluate the comprehensive effects of OCR in and colon cancer and its role in normalising tumour blood vessels.

RESULTS

, we found that OCR inhibited Human colon cancer cells (HCT116) and HUVEC cell proliferation and inhibited vascular endothelial growth factor-a (VEGFa) mRNA and protein expression in HUVECs in a co-culture system. Our studies showed that OCR inhibited colon cancer tumour growth, reduced angiogenesis in tumours and increased vascular endothelial (VE)-cadherin and pericyte coverage in tumour vessels.

CONCLUSIONS

OCR inhibited colon cancer growth both in and models, reduced angiogenesis in tumours, improved tumour vessel structures and normalised tumour vessels.