Li Ruiqiang, Zhan Wenqiang, Huang Xin, Wang Jiaqi, Lv ShuaiShuai, Liang Luyao, Zhang Fan, Ma Yuxia
Department of Nutrition and Food Hygiene, School of Public Health, Hebei Province Key Laboratory of Environment and Human Health, Hebei Medical University, Shijiazhuang, China.
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China.
Int J Gynaecol Obstet. 2022 Sep;158(3):663-670. doi: 10.1002/ijgo.14024. Epub 2021 Dec 4.
The purpose of this study was to determine the relationship between the Dietary Inflammatory Index (DII ) score and the bone health of menopausal women.
A total of 2461 participants were included in the analysis from the NHANES database 2009-2018 and 2005-2006. The association between the DII and Bone mineral density (BMD) and bone mineral content (BMC) was evaluated through a multiple linear regression model.
The mean DII in this study was +0.89 (SD 0.18) and the scores ranged from -5.46 (most anti-inflammatory) to +4.58 (most pro-inflammatory). After adjusting for confounding factors, higher DII is associated with an increased risk of decreased total bone density (Model III, β -0.012; 95% CI -0.023, -0.001). There is a similar correlation found in bone density content and other indicators of bone mineral density. At the same time, we used BMI as a stratified variable for subgroup analysis, we found that higher DII (continuous) was associated with a significantly higher risk of decreased total bone density in overweight/obese postmenopausal women (β -0.018; 95% CI -0.025, -0.006).
A higher DII score is significantly associated with lower bone density and bone density in postmenopausal women, especially women who are overweight/obese.
本研究旨在确定饮食炎症指数（DII）评分与绝经后女性骨骼健康之间的关系。
从2009 - 2018年和2005 - 2006年的美国国家健康与营养检查调查（NHANES）数据库中纳入了2461名参与者进行分析。通过多元线性回归模型评估DII与骨矿物质密度（BMD）和骨矿物质含量（BMC）之间的关联。
本研究中DII的平均值为+0.89（标准差0.18），评分范围从-5.46（最具抗炎性）到+4.58（最具促炎性）。在调整混杂因素后，较高的DII与总骨密度降低风险增加相关（模型III，β -0.012；95%置信区间-0.023，-0.001）。在骨密度含量和其他骨矿物质密度指标中也发现了类似的相关性。同时，我们将体重指数（BMI）作为分层变量进行亚组分析，发现较高的DII（连续变量）与超重/肥胖绝经后女性总骨密度降低的风险显著更高相关（β -0.018；95%置信区间-0.025，-0.006）。
较高的DII评分与绝经后女性较低的骨密度显著相关，尤其是超重/肥胖的女性。
